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SAP18 cdna clone

Scan QR to view Datasheet Catalog #    MBS1272100 SAP18 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SAP18, cDNA Clone

★Popular Item★
 Also Known As   

SAP18 cDNA Clone

 Product Gene Name   

SAP18 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcggtgg agtcgcgcgt tacccaggag gaaattaaga aggagccaga gaaaccgatc gaccgcgaga agacatgccc actgttgcta cgggtcttca ccaccaataa cggccgccac caccgaatgg acgagttctc ccggggaaat gtaccgtcca gcgagttgca gatctacact tggatggatg caactttgaa agaactgaca agcttagtaa aagaagtcta cccagaagct agaaagaagg gcactcactt caattttgca atcgttttta cagatgttaa aagacctggc tatcgagtta aggaaattgg cagcaccatg tctggcagaa aggggactga tgattccatg accctgcagt cgcagaagtt ccagatagga gattacttgg acatagcaat tacccctcca aatcgggcac cacctacttc agggcgcatg agaccatatt aa
 OMIM    602949
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SAP18 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SAP18. It may not necessarily be applicable to this product.
 NCBI GI #    21410830
 NCBI GeneID    10284
 NCBI Accession #    BC030836 [Other Products]
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 UniProt Secondary Accession #    Q2TTR4; Q6IAW9; Q8N606; Q9UF14; B2R494 [Other Products]
 UniProt Related Accession #    O00422 [Other Products]
 Molecular Weight    17,561 Da
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 NCBI Official Full Name    Homo sapiens Sin3A-associated protein, 18kDa, mRNA
 NCBI Official Synonym Full Names    Sin3A associated protein 18
 NCBI Official Symbol    SAP18 [Similar Products]
 NCBI Official Synonym Symbols   
SAP18P; 2HOR0202
[Similar Products]
 NCBI Protein Information    histone deacetylase complex subunit SAP18
 UniProt Protein Name    Histone deacetylase complex subunit SAP18
 UniProt Synonym Protein Names   
18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18
 Protein Family    Zinc finger A20 domain-containing stress-associated protein
 UniProt Gene Name    SAP18 [Similar Products]
 UniProt Entry Name    SAP18_HUMAN
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 NCBI Summary for SAP18    Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
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 UniProt Comments for SAP18    SAP18: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family.

Chromosomal Location of Human Ortholog: 13q12.11

Cellular Component: cytoplasm; histone deacetylase complex; nuclear speck; nucleoplasm

Molecular Function: histone deacetylase activity; protein binding; transcription corepressor activity

Biological Process: negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of apoptosis; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of transcription from RNA polymerase II promoter
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 Research Articles on SAP18    1. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SAP18 cdna cloneDiseases associated with SAP18 cdna clone
 Products by Pathway  Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with SAP18 and Neoplasms
Organs/Tissues associated with SAP18 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with SAP18 and Bone
 Muscle Antibodies  >2 publications with SAP18 and Muscle
 Ovary Antibodies  >2 publications with SAP18 and Ovary
 Embryonic Tissue Antibodies  >2 publications with SAP18 and Embryonic Tissue
 Salivary Gland Antibodies  >1 publications with SAP18 and Salivary Gland
 Mouth Antibodies  >1 publications with SAP18 and Mouth
 Testis Antibodies  >1 publications with SAP18 and Testis
 Brain Antibodies  >1 publications with SAP18 and Brain
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