BC063800
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,187 Da
NCBI Official Full Name
Homo sapiens SEC23 interacting protein, mRNA
NCBI Official Synonym Full Names
SEC23 interacting protein
NCBI Protein Information
SEC23-interacting protein
UniProt Protein Name
SEC23-interacting protein
UniProt Synonym Protein Names
p125
UniProt Entry Name
S23IP_HUMAN
NCBI Summary for SEC23IP
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for SEC23IP
SEC23IP: Plays a role in the organization of endoplasmic reticulum exit sites. Belongs to the PA-PLA1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 10q25-q26
Cellular Component: cytoplasm; cytosol; ER to Golgi transport vesicle; ER-Golgi intermediate compartment
Molecular Function: phospholipase activity; protein binding
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; intracellular protein transport
Research Articles on SEC23IP
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Diseases associated with SEC23IP cdna clone
Organs/Tissues associated with SEC23IP cdna clone
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