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SETD2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275087
SDS-PAGE
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SETD2, cDNA Clone

★Popular Item★
 Also Known As   

SETD2 cDNA Clone

 Product Gene Name   

SETD2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    144700
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SETD2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 SDS-PAGE of SETD2 cdna clone    SETD2 cdna clone SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for SETD2. It may not necessarily be applicable to this product.
 NCBI GI #    109658483
 NCBI GeneID    29072
 NCBI Accession #    BC117162 [Other Products]
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 UniProt Secondary Accession #    O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0 [Other Products]
 UniProt Related Accession #    Q9BYW2 [Other Products]
 Molecular Weight    175,982 Da
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 NCBI Official Full Name    Homo sapiens SET domain containing 2, mRNA
 NCBI Official Synonym Full Names    SET domain containing 2
 NCBI Official Symbol    SETD2 [Similar Products]
 NCBI Official Synonym Symbols   
LLS; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
[Similar Products]
 NCBI Protein Information    histone-lysine N-methyltransferase SETD2
 UniProt Protein Name    Histone-lysine N-methyltransferase SETD2
 UniProt Synonym Protein Names   
HIF-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A; SET domain-containing protein 2; hSET2; p231HBP
 Protein Family    Histone-lysine N-methyltransferase
 UniProt Gene Name    SETD2 [Similar Products]
 UniProt Synonym Gene Names    HIF1; HYPB; KIAA1732; KMT3A; SET2; HIP-1; hSET2 [Similar Products]
 UniProt Entry Name    SETD2_HUMAN
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 NCBI Summary for SETD2    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
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 UniProt Comments for SETD2    SETD2: Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Belongs to the histone-lysine methyltransferase family. SET2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K36 specific); histone-lysine N-methyltransferase activity; protein binding

Biological Process: mismatch repair; RNA elongation from RNA polymerase II promoter

Disease: Luscan-lumish Syndrome
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 Research Articles on SETD2    1. This study provides evidence for HOTAIR to promote tumorigenesis via downregulating SETD2 in liver cancer stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SETD2 cdna cloneDiseases associated with SETD2 cdna clone
 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma, Renal Cell Antibodies  >14 publications with SETD2 and Carcinoma, Renal Cell
 Kidney Neoplasms Antibodies  >9 publications with SETD2 and Kidney Neoplasms
 Adenocarcinoma Antibodies  >9 publications with SETD2 and Adenocarcinoma
 Kidney Diseases Antibodies  >9 publications with SETD2 and Kidney Diseases
 Chromosome Aberrations Antibodies  >2 publications with SETD2 and Chromosome Aberrations
 Neoplasm Metastasis Antibodies  >2 publications with SETD2 and Neoplasm Metastasis
Organs/Tissues associated with SETD2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >10 publications with SETD2 and Kidney
 Blood Antibodies  >2 publications with SETD2 and Blood
 Placenta Antibodies  >1 publications with SETD2 and Placenta
 Embryonic Tissue Antibodies  >1 publications with SETD2 and Embryonic Tissue
 Lung Antibodies  >1 publications with SETD2 and Lung
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