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| Product Name
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SLC3A2, cDNA Clone
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| Also Known As
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SLC3A2 cDNA Clone
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| Molecular Biology Protocol
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| Frequently Asked Questions
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| Sequence
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Please Inquire
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| OMIM
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158070
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| Vector
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Please Inquire
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of SLC3A2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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| NCBI/Uniprot data below describe general gene information for SLC3A2. It may not necessarily be applicable to this product. |
| NCBI GI #
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33875944
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| NCBI GeneID
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6520
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| NCBI Accession #
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BC001061
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[Other Products]
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| UniProt Secondary Accession #
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Q13543
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[Other Products]
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| UniProt Related Accession #
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P08195
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[Other Products]
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| Molecular Weight
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71,123 Da
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| NCBI Official Full Name
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Homo sapiens solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, mRNA
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| NCBI Official Synonym Full Names
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solute carrier family 3 member 2
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| NCBI Official Symbol
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SLC3A2
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[Similar Products]
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| NCBI Official Synonym Symbols
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4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC
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[Similar Products]
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| NCBI Protein Information
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4F2 cell-surface antigen heavy chain
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| UniProt Protein Name
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4F2 cell-surface antigen heavy chain
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| UniProt Synonym Protein Names
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4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; Solute carrier family 3 member 2; CD_antigen: CD98
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| Protein Family
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4F2 cell-surface antigen
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| UniProt Gene Name
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SLC3A2
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[Similar Products]
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| UniProt Synonym Gene Names
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MDU1; 4F2hc
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[Similar Products]
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| UniProt Entry Name
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4F2_HUMAN
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| NCBI Summary for SLC3A2
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This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
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| UniProt Comments for SLC3A2
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SLC3A2: a transmembrane solute carrier protein that transports L-type amino acids and regulates intracellular calcium levels. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins. Interacts with FAM57A and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1. Expression is induced in resting peripheral blood T- lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesi, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Belongs to the SLC3A transporter family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: cell surface; cell-cell adherens junction; cytoplasm; membrane; nucleus; plasma membrane
Molecular Function: calcium:sodium antiporter activity; double-stranded RNA binding; neutral amino acid transmembrane transporter activity; protein binding
Biological Process: amino acid transport; leukocyte migration; response to exogenous dsRNA; tryptophan transport
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| Research Articles on SLC3A2
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1. exposure to diesel exhaust particle extract induces functional overexpression of the amino acid transporter LAT1/CD98hc in lung cells
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Pathways associated with SLC3A2 cdna clone | Diseases associated with SLC3A2 cdna clone |
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| Organs/Tissues associated with SLC3A2 cdna clone |
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cDNA Clone 
