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SPATA7 cdna clone

Scan QR to view Datasheet Catalog #    MBS1267798 SPATA7 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SPATA7, cDNA Clone

 Also Known As   

SPATA7 cDNA Clone

 Product Gene Name   

SPATA7 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgacagatt cagaaatgaa cataaagcag gcatctaatt gtgtgacata tgatgccaaa gaaaaaatag ctcctttacc tttagaaggg catgactcaa catgggatga gattaaggat gatgctcttc agcattcctc accaagggca atgtgtcagt attccctgaa gcccccttca actcgtaaaa tctactctga tgaagaagaa ctgttgtatc tgagtttcat tgaagatgta acagatgaaa ttttgaaact tggtttattt tcaaacaggt ttttagaacg actgttcgag cgacatataa aacaaaataa acatttggag gaggaaaaaa tgcgccacct gctgcatgtc ctgaaagtag acttaggctg cacatcggag gaaaactcgg taaagcaaaa tgatgttgat atgttgaatg tatttgattt tgaaaaggct gggaattcag aaccaaatga attaaaaaat gaaagtgaag taacaattca gcaggaacgt caacaatacc aaaaggcttt ggatatgtta ttgtcggcac caaaggatga gaacgagata ttcccttcac caactgaatt tttcatgcct atttataaat caaagcattc agaaggggtt ataattcaac aggtgaatga tgaaacaaat cttgaaactt caactttgga tgaaaatcat ccaagtattt cagacagttt aacagatcgg gaaacttctg tgaatgtcat tgaaggtgat agtgaccctg aaaaggttga gatttcaaat ggattatgtg gtcttaacac atcaccctcc caatctgttc agttctccag tgtcaaaggc gacaataatc atgacatgga gttatcaact cttaaaatca tggaaatgag cattgaggac tgccctttgg atgtttaa
 OMIM    268000
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SPATA7 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SPATA7. It may not necessarily be applicable to this product.
 NCBI GI #    14250441
 NCBI GeneID    55812
 NCBI Accession #    BC008656 [Other Products]
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 UniProt Secondary Accession #    Q5BKY5; Q8WX30; Q96HF3; Q9H0X0; Q9P0W7 [Other Products]
 UniProt Related Accession #    Q9P0W8 [Other Products]
 Molecular Weight    51,931 Da
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 NCBI Official Full Name    Homo sapiens spermatogenesis associated 7, mRNA
 NCBI Official Synonym Full Names    spermatogenesis associated 7
 NCBI Official Symbol    SPATA7 [Similar Products]
 NCBI Official Synonym Symbols   
HSD3; LCA3; HSD-3.1; HEL-S-296
[Similar Products]
 NCBI Protein Information    spermatogenesis-associated protein 7
 UniProt Protein Name    Spermatogenesis-associated protein 7
 UniProt Synonym Protein Names   
HSD-3.1; Spermatogenesis-associated protein HSD3
 Protein Family    Spermatogenesis-associated protein
 UniProt Gene Name    SPATA7 [Similar Products]
 UniProt Synonym Gene Names    HSD3 [Similar Products]
 UniProt Entry Name    SPAT7_HUMAN
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 NCBI Summary for SPATA7    This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
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 UniProt Comments for SPATA7    SPATA7: May be involved in retinal function. Defects in SPATA7 are the cause of Leber congenital amaurosis type 3 (LCA3). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in SPATA7 are a cause of retinitis pigmentosa autosomal recessive (ARRP). ARRP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: axoneme; microtubule cytoskeleton; photoreceptor connecting cilium

Molecular Function: protein binding

Biological Process: photoreceptor cell maintenance

Disease: Leber Congenital Amaurosis 3
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 Research Articles on SPATA7    1. SPATA7 plays a role in RPGRIP1-mediated protein trafficking across the connecting cilium of photoreceptor cells. Apoptotic degeneration of these cells triggered by protein mislocalization is a mechanism of disease progression in LCA3/juvenile RP patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with SPATA7 cdna cloneOrgans/Tissues associated with SPATA7 cdna clone
 Disease Name  Pubmed Publications
 Leber Congenital Amaurosis Antibodies  >6 publications with SPATA7 and Leber Congenital Amaurosis
 Retinitis Pigmentosa Antibodies  >5 publications with SPATA7 and Retinitis Pigmentosa
 Neoplasms Antibodies  >3 publications with SPATA7 and Neoplasms
 Leber Congenital Amaurosis 3 Antibodies  >3 publications with SPATA7 and Leber Congenital Amaurosis 3
 Prostatic Neoplasms Antibodies  >2 publications with SPATA7 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >2 publications with SPATA7 and Prostatic Diseases
 Nervous System Diseases Antibodies  >1 publications with SPATA7 and Nervous System Diseases
 Carcinoma Antibodies  >1 publications with SPATA7 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >5 publications with SPATA7 and Eye
 Blood Antibodies  >2 publications with SPATA7 and Blood
 Prostate Antibodies  >2 publications with SPATA7 and Prostate
 Testis Antibodies  >2 publications with SPATA7 and Testis
 Adrenal Gland Antibodies  >1 publications with SPATA7 and Adrenal Gland
 Connective Tissue Antibodies  >1 publications with SPATA7 and Connective Tissue
 Brain Antibodies  >1 publications with SPATA7 and Brain
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