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SPDEF cdna clone

Scan QR to view Datasheet Catalog #    MBS1278768 SPDEF cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SPDEF, cDNA Clone

★Popular Item★
 Also Known As   

SPDEF cDNA Clone

 Product Gene Name   

SPDEF cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgggcagcg ccagcccggg tctgagcagc gtatccccca gccacctcct gctgcccccc gacacggtgt cgcggacagg cttggagaag gcggcagcgg gggcagtggg tctcgagaga cgggactgga gtcccagtcc acccgccacg cccgagcagg gcctgtccgc cttctacctc tcctactttg acatgctgta ccctgaggac agcagctggg cagccaaggc ccctggggcc agcagtcggg aggagccacc tgaggagcct gagcagtgcc cggtcattga cagccaagcc ccagcgggca gcctggactt ggtgcccggc gggctgacct tggaggagca ctcgctggag caggtgcagt ccatggtggt gggcgaagtg ctcaaggaca tcgagacggc ctgcaagctg ctcaacatca ccgcagatcc catggactgg agccccagca atgtgcagaa gtggctcctg tggacagagc accaataccg gctgcccccc atgggcaagg ccttccagga gctggcgggc aaggagctgt gcgccatgtc ggaggagcag ttccgccagc gctcgcccct gggtggggat gtgctgcacg cccacctgga catctggaag tcagcggcct ggatgaaaga gcggacttca cctggggcga ttcactactg tgcctcgacc agtgaggaga gctggaccga cagcgaggtg gactcatcat gctccgggca gcccatccac ctgtggcagt tcctcaagga gttgctactc aagccccaca gctatggccg cttcattagg tggctcaaca aggagaaggg catcttcaaa attgaggact cagcccaggt ggcccggctg tggggcatcc gcaagaaccg tcccgccatg aactacgaca agctgagccg ctccatccgc cagtattaca agaagggcat catccggaag ccagacatct cccagcgcct cgtctaccag ttcgtgcacc ccatctga
 OMIM    608144
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SPDEF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SPDEF. It may not necessarily be applicable to this product.
 NCBI GI #    33878542
 NCBI GeneID    25803
 NCBI Accession #    BC021299 [Other Products]
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 UniProt Secondary Accession #    B4DWH8; F5H778 [Other Products]
 UniProt Related Accession #    O95238 [Other Products]
 Molecular Weight    35,715 Da
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 NCBI Official Full Name    Homo sapiens SAM pointed domain containing ets transcription factor, mRNA
 NCBI Official Synonym Full Names    SAM pointed domain containing ETS transcription factor
 NCBI Official Symbol    SPDEF [Similar Products]
 NCBI Official Synonym Symbols   
PDEF; bA375E1.3
[Similar Products]
 NCBI Protein Information    SAM pointed domain-containing Ets transcription factor
 UniProt Protein Name    SAM pointed domain-containing Ets transcription factor
 UniProt Synonym Protein Names   
Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor
 Protein Family    SAM pointed domain-containing Ets transcription factor
 UniProt Gene Name    SPDEF [Similar Products]
 UniProt Synonym Gene Names    PDEF; PSE; Prostate-specific Ets [Similar Products]
 UniProt Entry Name    SPDEF_HUMAN
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 NCBI Summary for SPDEF    The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for SPDEF    SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleus

Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis
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 Research Articles on SPDEF    1. PDEF gene expression is associated with the extent of bladder neoplasia and PDEF modulated the expressions of EMT-related genes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SPDEF cdna cloneDiseases associated with SPDEF cdna clone
 Products by Pathway  Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >30 publications with SPDEF and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >16 publications with SPDEF and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >16 publications with SPDEF and Prostatic Diseases
 Neoplasm Metastasis Antibodies  >11 publications with SPDEF and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >9 publications with SPDEF and Adenocarcinoma
 Metaplasia Antibodies  >8 publications with SPDEF and Metaplasia
 Hyperplasia Antibodies  >7 publications with SPDEF and Hyperplasia
 Ovarian Neoplasms Antibodies  >5 publications with SPDEF and Ovarian Neoplasms
 Fibrosis Antibodies  >4 publications with SPDEF and Fibrosis
 Thyroid Diseases Antibodies  >2 publications with SPDEF and Thyroid Diseases
Organs/Tissues associated with SPDEF cdna clone
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >43 publications with SPDEF and Prostate
 Intestine Antibodies  >17 publications with SPDEF and Intestine
 Lung Antibodies  >16 publications with SPDEF and Lung
 Ovary Antibodies  >3 publications with SPDEF and Ovary
 Brain Antibodies  >2 publications with SPDEF and Brain
 Nerve Antibodies  >1 publications with SPDEF and Nerve
 Mammary Gland Antibodies  >1 publications with SPDEF and Mammary Gland
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