BC018137
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,533 Da
NCBI Official Full Name
Homo sapiens TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa, mRNA
NCBI Official Synonym Full Names
TATA-box binding protein associated factor, RNA polymerase I subunit B
NCBI Official Synonym Symbols
SL1; RAF1B; RAFI63; TAFI63; MGC:9349 [Similar Products]
NCBI Protein Information
TATA box-binding protein-associated factor RNA polymerase I subunit B
UniProt Protein Name
TATA box-binding protein-associated factor RNA polymerase I subunit B
UniProt Synonym Protein Names
RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B
UniProt Synonym Gene Names
UniProt Entry Name
TAF1B_HUMAN
NCBI Summary for TAF1B
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Comments for TAF1B
TAF1B: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription initiation complex; Nucleolus
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: nucleoplasm
Molecular Function: protein binding; TATA-binding protein binding
Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter
Research Articles on TAF1B
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Pathways associated with TAF1B cdna clone
Diseases associated with TAF1B cdna clone
Organs/Tissues associated with TAF1B cdna clone
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