BC008785
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,814 Da
NCBI Official Full Name
Homo sapiens TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa, mRNA
NCBI Official Synonym Full Names
TATA-box binding protein associated factor 6 like
NCBI Official Synonym Symbols
NCBI Protein Information
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
UniProt Protein Name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
UniProt Synonym Protein Names
PCAF-associated factor 65-alpha; PAF65-alpha
UniProt Synonym Gene Names
UniProt Entry Name
TAF6L_HUMAN
NCBI Summary for TAF6L
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
UniProt Comments for TAF6L
TAF6L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the TAF6 family.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component: histone deacetylase complex
Molecular Function: DNA binding; histone acetyltransferase activity; protein binding; transcription coactivator activity
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter
Research Articles on TAF6L
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Pathways associated with TAF6L cdna clone
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