BC015859
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,977 Da
NCBI Official Full Name
Homo sapiens T-cell activation RhoGTPase activating protein, mRNA
NCBI Official Synonym Full Names
T-cell activation RhoGTPase activating protein
NCBI Official Synonym Symbols
FKSG15; IDDM21; TAGAP1; ARHGAP47 [Similar Products]
NCBI Protein Information
T-cell activation Rho GTPase-activating protein
UniProt Protein Name
T-cell activation Rho GTPase-activating protein
UniProt Synonym Protein Names
T-cell activation GTPase-activating protein
UniProt Synonym Gene Names
UniProt Entry Name
TAGAP_HUMAN
NCBI Summary for TAGAP
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for TAGAP
TAGAP: an apparent GTPase-activating protein (GAP) for Rho monomeric G proteins. May play important roles during T-cell activation. Mutations have been associated with various autoimmune conditions including rheumatoid arthritis, Crohn¿s disease, and celiac disease. Four isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rac/Rho; GAPs
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: cytosol
Molecular Function: GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction
Research Articles on TAGAP
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Pathways associated with TAGAP cdna clone
Diseases associated with TAGAP cdna clone
Organs/Tissues associated with TAGAP cdna clone
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