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TARDBP cdna clone

Scan QR to view Datasheet Catalog #    MBS1268491 TARDBP cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TARDBP, cDNA Clone

 Also Known As   

TARDBP cDNA Clone

 Product Gene Name   

TARDBP cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    605078
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TARDBP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TARDBP. It may not necessarily be applicable to this product.
 NCBI GI #    47939519
 NCBI GeneID    23435
 NCBI Accession #    BC071657 [Other Products]
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 UniProt Secondary Accession #    Q53H27; Q6FI92; Q96DJ0; A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12 [Other Products]
 UniProt Related Accession #    Q13148 [Other Products]
 Molecular Weight    31,808 Da
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 NCBI Official Full Name    Homo sapiens TAR DNA binding protein, mRNA
 NCBI Official Synonym Full Names    TAR DNA binding protein
 NCBI Official Symbol    TARDBP [Similar Products]
 NCBI Official Synonym Symbols   
ALS10; TDP-43
[Similar Products]
 NCBI Protein Information    TAR DNA-binding protein 43
 UniProt Protein Name    TAR DNA-binding protein 43
 Protein Family    TAR DNA-binding protein
 UniProt Gene Name    TARDBP [Similar Products]
 UniProt Synonym Gene Names    TDP43; TDP-43 [Similar Products]
 UniProt Entry Name    TADBP_HUMAN
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 NCBI Summary for TARDBP    HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TARDBP    TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function: double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; protein binding; RNA binding; transcription factor activity

Biological Process: negative regulation of protein amino acid phosphorylation; nuclear fragmentation during apoptosis; regulation of cell cycle; RNA splicing

Disease: Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia
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 Research Articles on TARDBP    1. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 overexpression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with TARDBP cdna cloneOrgans/Tissues associated with TARDBP cdna clone
 Disease Name  Pubmed Publications
 Amyotrophic Lateral Sclerosis Antibodies  >145 publications with TARDBP and Amyotrophic Lateral Sclerosis
 Brain Diseases Antibodies  >56 publications with TARDBP and Brain Diseases
 Amyotrophic Lateral Sclerosis 10 Antibodies  >26 publications with TARDBP and Amyotrophic Lateral Sclerosis 10
 Atrophy Antibodies  >6 publications with TARDBP and Atrophy
 Cognition Disorders Antibodies  >5 publications with TARDBP and Cognition Disorders
 Neoplasms Antibodies  >4 publications with TARDBP and Neoplasms
 Inflammation Antibodies  >2 publications with TARDBP and Inflammation
 Fibrosis Antibodies  >2 publications with TARDBP and Fibrosis
 Genital Diseases, Male Antibodies  >2 publications with TARDBP and Genital Diseases, Male
 Learning Disorders Antibodies  >1 publications with TARDBP and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36 publications with TARDBP and Brain
 Muscle Antibodies  >17 publications with TARDBP and Muscle
 Nerve Antibodies  >12 publications with TARDBP and Nerve
 Blood Antibodies  >10 publications with TARDBP and Blood
 Embryonic Tissue Antibodies  >5 publications with TARDBP and Embryonic Tissue
 Testis Antibodies  >2 publications with TARDBP and Testis
 Heart Antibodies  >1 publications with TARDBP and Heart
 Vascular Antibodies  >1 publications with TARDBP and Vascular
 Prostate Antibodies  >1 publications with TARDBP and Prostate
 Liver Antibodies  >1 publications with TARDBP and Liver
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