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TCF4 cdna clone

Scan QR to view Datasheet Catalog #    MBS1274157 TCF4 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TCF4, cDNA Clone

★Popular Item★
 Also Known As   

TCF4 cDNA Clone

 Product Gene Name   

TCF4 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgcatcacc aacagcgaat ggctgcctta gggacggaca aagagctgag tgatttactg gatttcagtg cgatgttttc acctcctgtg agcagtggga aaaatggacc aacttctttg gcaagtggac attttactgg ctcaaatgta gaagacagaa gtagctcagg gtcctggggg aatggaggac atccaagccc gtccaggaac tatggagatg ggactcccta tgaccacatg accagcaggg accttgggtc acatgacaat ctctctccac cttttgtcaa ttccagaata caaagtaaaa cagaaagggg ctcatactca tcttatggga gagaatcaaa cttacagggt tgccaccagc agagtctcct tggaggtgac atggatatgg gcaacccagg aaccctttcg cccaccaaac ctggttccca gtactatcag tattctagca ataatccccg aaggaggcct cttcacagta gtgccatgga ggtacagaca aagaaagttc gaaaagttcc tccaggtttg ccatcttcag tctatgctcc atcagcaagc actgccgact acaataggga ctcgccaggc tatccttcct ccaaaccagc aaccagcact ttccctagct ccttcttcat gcaagatggc catcacagca gtgacccttg gagctcctcc agtgggatga atcagcctgg ctatgcagga atgttgggca actcttctca tattccacag tccagcagct actgtagcct gcatccacat gaacgtttga gctatccatc acactcctca gcagacatca attccagtct tcctccgatg tccactttcc atcgtagtgg tacaaaccat tacagcacct cttcctgtac gcctcctgcc aacgggacag acagtataat ggcaaataga ggaagcgggg cagccggcag ctcccagact ggagatgctc tggggaaagc acttgcttcg atctattctc cagatcacac taacaacagc ttttcatcaa acccttcaac tcctgttggc tctcctccat ctctctcagc aggcacagct gtttggtcta gaaattga
 OMIM    602272
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TCF4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TCF4. It may not necessarily be applicable to this product.
 NCBI GI #    21410271
 NCBI GeneID    6925
 NCBI Accession #    BC031056 [Other Products]
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 UniProt Secondary Accession #    B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; B7Z6Y1; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU4 [Other Products]
 UniProt Related Accession #    P15884 [Other Products]
 Molecular Weight    48,098 Da
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 NCBI Official Full Name    Homo sapiens transcription factor 4, mRNA
 NCBI Official Synonym Full Names    transcription factor 4
 NCBI Official Symbol    TCF4 [Similar Products]
 NCBI Official Synonym Symbols   
E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19
[Similar Products]
 NCBI Protein Information    transcription factor 4
 UniProt Protein Name    Transcription factor 4
 UniProt Synonym Protein Names   
Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2
 Protein Family    Transcription factor
 UniProt Gene Name    TCF4 [Similar Products]
 UniProt Synonym Gene Names    BHLHB19; ITF2; SEF2; TCF-4; bHLHb19; ITF-2; SEF-2 [Similar Products]
 UniProt Entry Name    ITF2_HUMAN
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 NCBI Summary for TCF4    This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
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 UniProt Comments for TCF4    TCF4: Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2. Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nuclear chromatin; nucleus; transcription factor complex

Molecular Function: bHLH transcription factor binding; DNA binding; identical protein binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity

Biological Process: positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein-DNA complex assembly; transcription initiation; transcription initiation from RNA polymerase II promoter

Disease: Corneal Dystrophy, Fuchs Endothelial, 3; Pitt-hopkins Syndrome
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 Research Articles on TCF4    1. the beta-catenin/Tcf4 interaction is disrupted by BC-23
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TCF4 cdna cloneDiseases associated with TCF4 cdna clone
 Products by Pathway  Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >438 publications with TCF4 and Neoplasms
 Liver Neoplasms Antibodies  >44 publications with TCF4 and Liver Neoplasms
 Liver Diseases Antibodies  >40 publications with TCF4 and Liver Diseases
 Pitt-Hopkins syndrome Antibodies  >38 publications with TCF4 and Pitt-Hopkins syndrome
 Breast Neoplasms Antibodies  >38 publications with TCF4 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >33 publications with TCF4 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >30 publications with TCF4 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >28 publications with TCF4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >22 publications with TCF4 and Lung Neoplasms
 Inflammation Antibodies  >21 publications with TCF4 and Inflammation
Organs/Tissues associated with TCF4 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >131 publications with TCF4 and Blood
 Intestine Antibodies  >112 publications with TCF4 and Intestine
 Nerve Antibodies  >95 publications with TCF4 and Nerve
 Brain Antibodies  >86 publications with TCF4 and Brain
 Liver Antibodies  >78 publications with TCF4 and Liver
 Embryonic Tissue Antibodies  >67 publications with TCF4 and Embryonic Tissue
 Pancreas Antibodies  >66 publications with TCF4 and Pancreas
 Muscle Antibodies  >45 publications with TCF4 and Muscle
 Kidney Antibodies  >39 publications with TCF4 and Kidney
 Lung Antibodies  >34 publications with TCF4 and Lung
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