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TIMP3 cdna clone

Scan QR to view Datasheet Catalog #    MBS1267145 TIMP3 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIMP3, cDNA Clone

★Popular Item★
 Also Known As   

TIMP3 cDNA Clone

 Product Gene Name   

TIMP3 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc ccggataaaa gcatcatcaa tgccacagac ccctga
 OMIM    136900
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TIMP3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TIMP3. It may not necessarily be applicable to this product.
 NCBI GI #    33878529
 NCBI GeneID    7078
 NCBI Accession #    BC014277 [Other Products]
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 UniProt Secondary Accession #    Q5THV4; Q9UC74; Q9UGS2; B2RBY9 [Other Products]
 UniProt Related Accession #    P35625 [Other Products]
 Molecular Weight    24,145 Da
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 NCBI Official Full Name    Homo sapiens TIMP metallopeptidase inhibitor 3, mRNA
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 3
 NCBI Official Symbol    TIMP3 [Similar Products]
 NCBI Official Synonym Symbols   
SFD; K222; K222TA2; HSMRK222
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 3
 UniProt Protein Name    Metalloproteinase inhibitor 3
 UniProt Synonym Protein Names   
Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP3 [Similar Products]
 UniProt Synonym Gene Names    TIMP-3 [Similar Products]
 UniProt Entry Name    TIMP3_HUMAN
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 NCBI Summary for TIMP3    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP3    TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: extracellular matrix; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix

Molecular Function: metalloendopeptidase inhibitor activity; protease binding; protein binding

Biological Process: negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; response to organic substance

Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
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 Research Articles on TIMP3    1. Genotypes of rs135025 and rs80272 in TIMP3 contribute to the development of preeclampsia in Han Chinese women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TIMP3 cdna cloneDiseases associated with TIMP3 cdna clone
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >236 publications with TIMP3 and Neoplasms
 Adenocarcinoma Antibodies  >63 publications with TIMP3 and Adenocarcinoma
 Necrosis Antibodies  >53 publications with TIMP3 and Necrosis
 Inflammation Antibodies  >47 publications with TIMP3 and Inflammation
 Breast Neoplasms Antibodies  >33 publications with TIMP3 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >33 publications with TIMP3 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >28 publications with TIMP3 and Carcinoma, Squamous Cell
 Liver Diseases Antibodies  >28 publications with TIMP3 and Liver Diseases
 Neoplasms, Experimental Antibodies  >25 publications with TIMP3 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >23 publications with TIMP3 and Liver Neoplasms
Organs/Tissues associated with TIMP3 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >61 publications with TIMP3 and Eye
 Vascular Antibodies  >61 publications with TIMP3 and Vascular
 Blood Antibodies  >55 publications with TIMP3 and Blood
 Liver Antibodies  >39 publications with TIMP3 and Liver
 Lung Antibodies  >38 publications with TIMP3 and Lung
 Muscle Antibodies  >26 publications with TIMP3 and Muscle
 Embryonic Tissue Antibodies  >26 publications with TIMP3 and Embryonic Tissue
 Kidney Antibodies  >25 publications with TIMP3 and Kidney
 Bone Antibodies  >24 publications with TIMP3 and Bone
 Heart Antibodies  >23 publications with TIMP3 and Heart
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