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TNFRSF10B cdna clone

Scan QR to view Datasheet Catalog #    MBS1273463 TNFRSF10B cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   


 Product Gene Name   

TNFRSF10B cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggaacaac ggggacagaa cgccccggcc gcttcggggg cccggaaaag gcacggccca ggacccaggg aggcgcgggg agccaggcct gggctccggg tccccaagac ccttgtgctc gttgtcgccg cggtcctgct gttggtctca gctgagtctg ctctgatcac ccaacaagac ctagctcccc agcagagagc ggccccacaa caaaagaggt ccagcccctc agagggattg tgtccacctg gacaccatat ctcagaagac ggtagagatt gcatctcctg caaatatgga caggactata gcactcactg gaatgacctc cttttctgct tgcgctgcac caggtgtgat tcaggtgaag tggagctaag tccctgcacc acgaccagaa acacagtgtg tcagtgcgaa gaaggcacct tccgggaaga agattctcct gagatgtgcc ggaagtgccg cacagggtgt cccagaggga tggtcaaggt cggtgattgt acaccctgga gtgacatcga atgtgtccac aaagaatcag gtacaaagca cagtggggaa gccccagctg tggaggagac ggtgacctcc agcccaggga ctcctgcctc tccctgttct ctctcaggca tcatcatagg agtcacagtt gcagccgtag tcttgattgt ggctgtgttt gtttgcaagt ctttactgtg gaagaaagtc cttccttacc tgaaaggcat ctgctcaggt ggtggtgggg accctgagcg tgtggacaga agctcacaac gacctggggc tgaggacaat gtcctcaatg agatcgtgag tatcttgcag cccacccagg tccctgagca ggaaatggaa gtccaggagc cagcagagcc aacaggtgtc aacatgttgt cccccgggga gtcagagcat ctgctggaac cggcagaagc tgaaaggtct cagaggagga ggctgctggt tccagcaaat gaaggtgatc ccactgagac tctgagacag tgcttcgatg actttgcaga cttggtgccc tttgactcct gggagccgct catgaggaag ttgggcctca tggacaatga gataaaggtg gctaaagctg aggcagcggg ccacagggac accttgtaca cgatgctgat aaagtgggtc aacaaaaccg ggcgagatgc ctctgtccac accctgctgg atgccttgga gacgctggga gagagacttg ccaagcagaa gattgaggac cacttgttga gctctggaaa gttcatgtat ctagaaggta atgcagactc tgccatgtcc taa
 OMIM    275355
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TNFRSF10B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TNFRSF10B. It may not necessarily be applicable to this product.
 NCBI GI #    12654874
 NCBI GeneID    8795
 NCBI Accession #    BC001281 [Other Products]
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 UniProt Secondary Accession #    O14720; O15508; O15517; O15531; Q6UXM8; Q7Z360; Q9BVE0 [Other Products]
 UniProt Related Accession #    O14763 [Other Products]
 Molecular Weight    45,083 Da
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 NCBI Official Full Name    Homo sapiens tumor necrosis factor receptor superfamily, member 10b, mRNA
 NCBI Official Synonym Full Names    TNF receptor superfamily member 10b
 NCBI Official Symbol    TNFRSF10B [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 10B
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 10B
 UniProt Synonym Protein Names   
Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF10B [Similar Products]
 UniProt Synonym Gene Names    DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2 [Similar Products]
 UniProt Entry Name    TR10B_HUMAN
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 NCBI Summary for TNFRSF10B    The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for TNFRSF10B    TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: cell surface; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity

Biological Process: caspase activation; cell surface receptor linked signal transduction; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide

Disease: Squamous Cell Carcinoma, Head And Neck
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 Research Articles on TNFRSF10B    1. Synthetic lipid bilayers displaying the membrane protein ligand Apo2L/TRAIL were used to stimulate death receptor-expressing cells in a modular, scalable format
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TNFRSF10B cdna cloneDiseases associated with TNFRSF10B cdna clone
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase-8 Activation Pathway antibodies  Caspase-8 Activation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1921 publications with TNFRSF10B and Necrosis
 Neoplasms Antibodies  >1539 publications with TNFRSF10B and Neoplasms
 Gastrointestinal Diseases Antibodies  >216 publications with TNFRSF10B and Gastrointestinal Diseases
 Drug Toxicity Antibodies  >169 publications with TNFRSF10B and Drug Toxicity
 Liver Diseases Antibodies  >150 publications with TNFRSF10B and Liver Diseases
 Breast Neoplasms Antibodies  >144 publications with TNFRSF10B and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >133 publications with TNFRSF10B and Neoplasms, Experimental
 Colonic Neoplasms Antibodies  >126 publications with TNFRSF10B and Colonic Neoplasms
 Liver Neoplasms Antibodies  >126 publications with TNFRSF10B and Liver Neoplasms
 Lung Neoplasms Antibodies  >126 publications with TNFRSF10B and Lung Neoplasms
Organs/Tissues associated with TNFRSF10B cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >438 publications with TNFRSF10B and Blood
 Liver Antibodies  >202 publications with TNFRSF10B and Liver
 Lung Antibodies  >170 publications with TNFRSF10B and Lung
 Prostate Antibodies  >153 publications with TNFRSF10B and Prostate
 Brain Antibodies  >93 publications with TNFRSF10B and Brain
 Vascular Antibodies  >69 publications with TNFRSF10B and Vascular
 Kidney Antibodies  >65 publications with TNFRSF10B and Kidney
 Skin Antibodies  >61 publications with TNFRSF10B and Skin
 Bone Marrow Antibodies  >56 publications with TNFRSF10B and Bone Marrow
 Muscle Antibodies  >34 publications with TNFRSF10B and Muscle
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