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TNR cdna clone

Scan QR to view Datasheet Catalog #    MBS1278275 TNR cdna clone
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 Product Name   

TNR, cDNA Clone

 Also Known As   

TNR cDNA Clone

 Product Gene Name   

TNR cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    601995
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TNR cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TNR. It may not necessarily be applicable to this product.
 NCBI GI #    120537313
 NCBI GeneID    7143
 NCBI Accession #    BC129830 [Other Products]
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 UniProt Secondary Accession #    Q15568; Q5R3G0; C9J563 [Other Products]
 UniProt Related Accession #    Q92752 [Other Products]
 Molecular Weight    139,695 Da
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 NCBI Official Full Name    Homo sapiens tenascin R (restrictin, janusin), mRNA
 NCBI Official Synonym Full Names    tenascin R
 NCBI Official Symbol    TNR [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    tenascin-R
 UniProt Protein Name    Tenascin-R
 UniProt Synonym Protein Names   
Janusin; Restrictin
 Protein Family    Tenascin
 UniProt Gene Name    TNR [Similar Products]
 UniProt Synonym Gene Names    TN-R [Similar Products]
 UniProt Entry Name    TENR_HUMAN
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 NCBI Summary for TNR    This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]
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 UniProt Comments for TNR    TNR: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. Belongs to the tenascin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: cytoplasm; extracellular region; nucleoplasm; nucleus

Biological Process: extracellular matrix organization and biogenesis
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 Research Articles on TNR    1. Two genes, TNR (and TNK2), were found to have genetic variations linked to familial Parkinson's Disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TNR cdna cloneDiseases associated with TNR cdna clone
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >41 publications with TNR and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >28 publications with TNR and Neurodegenerative Diseases
 Mental Disorders Antibodies  >22 publications with TNR and Mental Disorders
 Disease Models, Animal Antibodies  >9 publications with TNR and Disease Models, Animal
 Cognition Disorders Antibodies  >8 publications with TNR and Cognition Disorders
 Dementia Antibodies  >8 publications with TNR and Dementia
 Movement Disorders Antibodies  >8 publications with TNR and Movement Disorders
 Death Antibodies  >4 publications with TNR and Death
 Bone Diseases Antibodies  >2 publications with TNR and Bone Diseases
 Inflammation Antibodies  >2 publications with TNR and Inflammation
Organs/Tissues associated with TNR cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >32 publications with TNR and Brain
 Liver Antibodies  >16 publications with TNR and Liver
 Testis Antibodies  >2 publications with TNR and Testis
 Placenta Antibodies  >1 publications with TNR and Placenta
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