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TREX1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1276797 TREX1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TREX1, cDNA Clone

★Popular Item★
 Also Known As   

TREX1 cDNA Clone

 Product Gene Name   

TREX1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgggccctg gagctcgcag acagggcagg attgtgcagg gaaggcctga gatgtgcttc tgcccacccc ctaccccact ccctcccctt cggatcttaa cactgggcac tcacacaccc accccatgct cctctccagg ctcagcagca ggtacgtacc caaccatggg ctcgcaggcc ctgcccccgg ggcccatgca gaccctcatc tttttcgaca tggaggccac tggcttgccc ttctcccagc ccaaggtcac ggagctgtgc ctgctggctg tccacagatg tgccctggag agccccccca cctctcaggg gccacctccc acagttcctc caccaccgcg tgtggtagac aagctctccc tgtgtgtggc tccggggaag gcctgcagcc ctgcagccag cgagatcaca ggtctgagca cagctgtgct ggcagcgcat gggcgtcaat gttttgatga caacctggcc aacctgctcc tagccttcct gcggcgccag ccacagccct ggtgcctggt ggcacacaat ggtgaccgct acgacttccc cctgctccaa gcagagctgg ctatgctggg cctcaccagt gctctggatg gtgccttctg tgtggatagc atcactgcgc tgaaggccct ggagcgagca agcagcccct cagaacacgg cccaaggaag agctacagcc taggcagcat ctacactcgc ctgtatgggc agtcccctcc agactcgcac acggctgagg gtgatgtcct ggccctgctc agcatctgtc agtggagacc acaggccctg ctgcggtggg tggatgctca cgccaggcct ttcggcacca tcaggcccat gtatggggtc acagcctctg ctaggaccaa gccaagacca tctgctgtca caaccactgc acacctggcc acaaccagga acactagtcc cagccttgga gagagcaggg gtaccaagga tcttcctcca gtgaaggacc ctggagccct atccagggag gggctgctgg ccccactggg tctgctggcc atcctgacct tggcagtagc cacactgtat ggactatccc tggccacacc tggggagtag
 OMIM    152700
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TREX1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TREX1. It may not necessarily be applicable to this product.
 NCBI GI #    23272144
 NCBI GeneID    11277
 NCBI Accession #    BC023630 [Other Products]
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 UniProt Secondary Accession #    Q8TEU2; Q9BPW1; Q9Y4X2; B2RCN9 [Other Products]
 UniProt Related Accession #    Q9NSU2 [Other Products]
 Molecular Weight    33,212 Da
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 NCBI Official Full Name    Homo sapiens three prime repair exonuclease 1, mRNA
 NCBI Official Synonym Full Names    three prime repair exonuclease 1
 NCBI Official Symbol    TREX1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    three-prime repair exonuclease 1
 UniProt Protein Name    Three-prime repair exonuclease 1
 UniProt Synonym Protein Names   
3'-5' exonuclease TREX1; DNase III
 Protein Family    Three-prime repair exonuclease
 UniProt Gene Name    TREX1 [Similar Products]
 UniProt Entry Name    TREX1_HUMAN
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 NCBI Summary for TREX1    This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
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 UniProt Comments for TREX1    TREX1: the major 3' DNA exonuclease in mammalian cells. Normally associates with the endoplasmic reticulum (ER). Translocates to the nucleus at S phase after DNA damage by gamma-irradiation or hydroxyurea. Trex1-deficient cells show defective G1/S transition, with single-stranded DNA molecules persisting after S phase and accumulating in the ER. Degrades ssDNA. Prevents chronic checkpoint activation and inappropriate immune activation. Mutations cause Aicardi-Goutieres syndrome, an autoimmune disorder. Trex1a(-/-) mice have autoinflammatory responses. The gene for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode TREX1 also encode ATRIP in another reading frame. Three alternatively spliced human isoforms have been reported.

Protein type: EC; DNA repair, damage; Cell cycle regulation; Deoxyribonuclease; DNA-binding

Chromosomal Location of Human Ortholog: 3p21.31

Disease: Aicardi-goutieres Syndrome 1; Chilblain Lupus 1; Systemic Lupus Erythematosus; Vasculopathy, Retinal, With Cerebral Leukodystrophy
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 Research Articles on TREX1    1. Aicardi-Goutieres syndrome 1 is caused by mutations in the three prime repair exonuclease 1 gene (TREX1, MIM 606609).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TREX1 cdna cloneDiseases associated with TREX1 cdna clone
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Disease Name  Pubmed Publications
 Aicardi-Goutieres syndrome Antibodies  >43 publications with TREX1 and Aicardi-Goutieres syndrome
 Nervous System Diseases Antibodies  >33 publications with TREX1 and Nervous System Diseases
 Lupus Erythematosus, Systemic Antibodies  >30 publications with TREX1 and Lupus Erythematosus, Systemic
 Brain Diseases Antibodies  >22 publications with TREX1 and Brain Diseases
 Chilblain lupus Antibodies  >17 publications with TREX1 and Chilblain lupus
 Congenital Abnormalities Antibodies  >14 publications with TREX1 and Congenital Abnormalities
 Vasculopathy, Retinal, With Cerebral Leukodystrophy Antibodies  >8 publications with TREX1 and Vasculopathy, Retinal, With Cerebral Leukodystrophy
 Inflammation Antibodies  >8 publications with TREX1 and Inflammation
 Neurodegenerative Diseases Antibodies  >5 publications with TREX1 and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >3 publications with TREX1 and Disease Models, Animal
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