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TRIP12 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270474 TRIP12 cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRIP12, cDNA Clone

 Also Known As   

TRIP12 cDNA Clone

 Product Gene Name   

TRIP12 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    604506
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TRIP12 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TRIP12. It may not necessarily be applicable to this product.
 NCBI GI #    109731502
 NCBI GeneID    9320
 NCBI Accession #    BC114556 [Other Products]
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 UniProt Secondary Accession #    Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7; D4HL82 [Other Products]
 UniProt Related Accession #    Q14669 [Other Products]
 Molecular Weight    192,075 Da
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 NCBI Official Full Name    Homo sapiens thyroid hormone receptor interactor 12, mRNA
 NCBI Official Synonym Full Names    thyroid hormone receptor interactor 12
 NCBI Official Symbol    TRIP12 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase TRIP12
 UniProt Protein Name    E3 ubiquitin-protein ligase TRIP12
 UniProt Synonym Protein Names   
E3 ubiquitin-protein ligase for Arf; ULF; Thyroid receptor-interacting protein 12; TR-interacting protein 12; TRIP-12
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    TRIP12 [Similar Products]
 UniProt Synonym Gene Names    KIAA0045; ULF; ULF; TR-interacting protein 12; TRIP-12 [Similar Products]
 UniProt Entry Name    TRIPC_HUMAN
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 UniProt Comments for TRIP12    TRIP12: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Belongs to the UPL family. K-HECT subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; EC; EC 6.3.2.-; Nuclear receptor co-regulator; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2q36.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding; thyroid hormone receptor binding; ubiquitin-protein ligase activity

Biological Process: embryonic development; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to DNA damage stimulus
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 Research Articles on TRIP12    1. Data indicate that E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a)and regulates PTF1a activities.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TRIP12 cdna cloneDiseases associated with TRIP12 cdna clone
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with TRIP12 and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with TRIP12 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with TRIP12 and Kidney Diseases
 Necrosis Antibodies  >1 publications with TRIP12 and Necrosis
Organs/Tissues associated with TRIP12 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with TRIP12 and Muscle
 Nerve Antibodies  >1 publications with TRIP12 and Nerve
 Blood Antibodies  >1 publications with TRIP12 and Blood
 Thyroid Antibodies  >1 publications with TRIP12 and Thyroid
 Stomach Antibodies  >1 publications with TRIP12 and Stomach
 Kidney Antibodies  >1 publications with TRIP12 and Kidney
 Skin Antibodies  >1 publications with TRIP12 and Skin
 Brain Antibodies  >1 publications with TRIP12 and Brain
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