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TTR cdna clone

Scan QR to view Datasheet Catalog #    MBS1270491 TTR cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TTR, cDNA Clone

★Popular Item★
 Also Known As   

TTR cDNA Clone

 Product Gene Name   

TTR cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct ggccctacgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct gtcgtcacca atcccaagga atga
 OMIM    105210
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TTR cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TTR. It may not necessarily be applicable to this product.
 NCBI GI #    13529049
 NCBI GeneID    7276
 NCBI Accession #    BC005310 [Other Products]
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 UniProt Secondary Accession #    Q549C7; Q6IB96; Q9UBZ6; Q9UCM9 [Other Products]
 UniProt Related Accession #    P02766 [Other Products]
 Molecular Weight    15,887 Da
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 NCBI Official Full Name    Homo sapiens transthyretin, mRNA
 NCBI Official Synonym Full Names    transthyretin
 NCBI Official Symbol    TTR [Similar Products]
 NCBI Official Synonym Symbols   
CTS; CTS1; PALB; TBPA; HEL111; HsT2651
[Similar Products]
 NCBI Protein Information    transthyretin
 UniProt Protein Name    Transthyretin
 UniProt Synonym Protein Names   
ATTR; Prealbumin; TBPA
 Protein Family    Transthyretin
 UniProt Gene Name    TTR [Similar Products]
 UniProt Synonym Gene Names    PALB [Similar Products]
 UniProt Entry Name    TTHY_HUMAN
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 NCBI Summary for TTR    This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
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 UniProt Comments for TTR    TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: extracellular region; extracellular space

Molecular Function: identical protein binding; protein binding

Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; purine base metabolic process; retinoid metabolic process

Disease: Amyloidosis, Hereditary, Transthyretin-related; Carpal Tunnel Syndrome; Hyperthyroxinemia, Dystransthyretinemic
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 Research Articles on TTR    1. Data suggest that well-structured AB loop regions of TTR in native/homotetrameric/stable state become dissociated/disordered/unfolded at low pH; during refolding, structural perturbations in AB loop appear and facilitate misfolding and amyloid formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TTR cdna cloneDiseases associated with TTR cdna clone
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >556 publications with TTR and Nervous System Diseases
 Amyloidosis, Familial Antibodies  >502 publications with TTR and Amyloidosis, Familial
 Amyloid Neuropathies, Familial Antibodies  >345 publications with TTR and Amyloid Neuropathies, Familial
 Neoplasms Antibodies  >198 publications with TTR and Neoplasms
 Heart Diseases Antibodies  >146 publications with TTR and Heart Diseases
 Brain Diseases Antibodies  >114 publications with TTR and Brain Diseases
 Liver Diseases Antibodies  >96 publications with TTR and Liver Diseases
 Drug Toxicity Antibodies  >76 publications with TTR and Drug Toxicity
 Inflammation Antibodies  >55 publications with TTR and Inflammation
 Immune System Diseases Antibodies  >51 publications with TTR and Immune System Diseases
Organs/Tissues associated with TTR cdna clone
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >414 publications with TTR and Liver
 Brain Antibodies  >210 publications with TTR and Brain
 Heart Antibodies  >193 publications with TTR and Heart
 Muscle Antibodies  >109 publications with TTR and Muscle
 Kidney Antibodies  >102 publications with TTR and Kidney
 Eye Antibodies  >80 publications with TTR and Eye
 Skin Antibodies  >49 publications with TTR and Skin
 Lung Antibodies  >43 publications with TTR and Lung
 Embryonic Tissue Antibodies  >30 publications with TTR and Embryonic Tissue
 Pancreas Antibodies  >30 publications with TTR and Pancreas
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