BC005979
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,312 Da
NCBI Official Full Name
Homo sapiens ubiquitin-conjugating enzyme E2B (RAD6 homolog), mRNA
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 B
NCBI Official Synonym Symbols
HR6B; UBC2; HHR6B; RAD6B; E2-17kDa [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 B
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 B
UniProt Synonym Protein Names
E2 ubiquitin-conjugating enzyme B; RAD6 homolog B; HR6B; hHR6B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B
UniProt Synonym Gene Names
UniProt Entry Name
UBE2B_HUMAN
NCBI Summary for UBE2B
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
UniProt Comments for UBE2B
UBE2B: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ligase
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: chromatin; cytoplasm; nuclear chromatin; nucleoplasm; nucleus; replication fork
Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: DNA damage response, detection of DNA damage; DNA repair; histone H2A ubiquitination; postreplication repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein monoubiquitination; protein polyubiquitination; protein stabilization; protein ubiquitination; response to DNA damage stimulus; response to drug; response to UV; spermatogenesis; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin
Research Articles on UBE2B
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Pathways associated with UBE2B cdna clone
Diseases associated with UBE2B cdna clone
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