BC005980
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,602 Da
NCBI Official Full Name
Homo sapiens ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast), mRNA
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 D1
NCBI Official Synonym Symbols
SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1 [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 D1
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 D1
UniProt Synonym Protein Names
(E3-independent) E2 ubiquitin-conjugating enzyme D1 (EC:2.3.2.24
UniProt Synonym Gene Names
UniProt Entry Name
UB2D1_HUMAN
NCBI Summary for UBE2D1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Comments for UBE2D1
UBE2D1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 10q21.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; protein complex; ubiquitin ligase complex
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; ubiquitin-dependent protein catabolic process
Research Articles on UBE2D1
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Pathways associated with UBE2D1 cdna clone
Diseases associated with UBE2D1 cdna clone
Organs/Tissues associated with UBE2D1 cdna clone
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