BC001738
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,614 Da
NCBI Official Full Name
Homo sapiens ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), mRNA
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 G2
NCBI Official Synonym Symbols
NCBI Protein Information
ubiquitin-conjugating enzyme E2 G2
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 G2
UniProt Synonym Protein Names
E2 ubiquitin-conjugating enzyme G2; Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2
UniProt Entry Name
UB2G2_HUMAN
NCBI Summary for UBE2G2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for UBE2G2
UBE2G2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). Belongs to the ubiquitin-conjugating enzyme family.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: cellular protein catabolic process; ER-associated protein catabolic process; protein amino acid N-linked glycosylation via asparagine; ubiquitin-dependent protein catabolic process
Research Articles on UBE2G2
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Pathways associated with UBE2G2 cdna clone
Diseases associated with UBE2G2 cdna clone
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