BC113430
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,972 Da
NCBI Official Full Name
Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 J2
NCBI Protein Information
ubiquitin-conjugating enzyme E2 J2
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 J2
UniProt Synonym Protein Names
E2 ubiquitin-conjugating enzyme J2; Non-canonical ubiquitin-conjugating enzyme 2; NCUBE-2
UniProt Synonym Gene Names
UniProt Entry Name
UB2J2_HUMAN
NCBI Summary for UBE2J2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
UniProt Comments for UBE2J2
UBE2J2: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ligase; Membrane protein, integral; Ubiquitin conjugating system; EC 6.3.2.19; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: endoplasmic reticulum; ubiquitin ligase complex
Molecular Function: ubiquitin protein ligase binding
Biological Process: ER-associated protein catabolic process; protein polyubiquitination
Research Articles on UBE2J2
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Pathways associated with UBE2J2 cdna clone
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