BC041156
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,079 Da
NCBI Official Full Name
Homo sapiens unc-5 homolog C (C. elegans), mRNA
NCBI Official Synonym Full Names
unc-5 netrin receptor C
NCBI Official Synonym Symbols
NCBI Protein Information
netrin receptor UNC5C
UniProt Protein Name
Netrin receptor UNC5C
UniProt Synonym Protein Names
Protein unc-5 homolog 3; Protein unc-5 homolog C
UniProt Synonym Gene Names
UniProt Entry Name
UNC5C_HUMAN
NCBI Summary for UNC5C
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
UniProt Comments for UNC5C
UNC5C: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 4q21-q23
Biological Process: axon guidance
Research Articles on UNC5C
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Pathways associated with UNC5C cdna clone
Diseases associated with UNC5C cdna clone
Organs/Tissues associated with UNC5C cdna clone
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