BC107098
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,020 Da
NCBI Official Full Name
Homo sapiens uroplakin 1A, mRNA
NCBI Official Synonym Full Names
uroplakin 1A
NCBI Protein Information
uroplakin-1a
UniProt Protein Name
Uroplakin-1a
UniProt Synonym Protein Names
Tetraspanin-21; Tspan-21; Uroplakin Ia; UPIa; UPKa
UniProt Synonym Gene Names
UniProt Entry Name
UPK1A_HUMAN
NCBI Summary for UPK1A
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for UPK1A
UPK1A: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Belongs to the tetraspanin (TM4SF) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: endoplasmic reticulum; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: monosaccharide binding; protein homodimerization activity
Biological Process: cell surface receptor linked signal transduction; epithelial cell differentiation; protein oligomerization
Research Articles on UPK1A
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Diseases associated with UPK1A cdna clone
Organs/Tissues associated with UPK1A cdna clone
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