BC068490
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,346 Da
NCBI Official Full Name
Homo sapiens vascular cell adhesion molecule 1, mRNA
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Protein Information
vascular cell adhesion protein 1
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
INCAM-100; CD_antigen: CD106
UniProt Synonym Gene Names
UniProt Entry Name
VCAM1_HUMAN
NCBI Summary for VCAM1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for VCAM1
VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; microvillus; plasma membrane; podosome
Molecular Function: amine oxidase activity; cell adhesion molecule binding; integrin binding
Biological Process: amine metabolic process; B cell differentiation; cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; membrane to membrane docking; positive regulation of T cell proliferation; regulation of immune response
Research Articles on VCAM1
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Pathways associated with VCAM1 cdna clone
Diseases associated with VCAM1 cdna clone
Organs/Tissues associated with VCAM1 cdna clone
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