BC126147
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,844 Da
NCBI Official Full Name
Homo sapiens vanin 2, mRNA
NCBI Official Synonym Full Names
vanin 2
NCBI Protein Information
vascular non-inflammatory molecule 2
UniProt Protein Name
Vascular non-inflammatory molecule 2
UniProt Synonym Protein Names
Glycosylphosphatidyl inositol-anchored protein GPI-80; Protein FOAP-4
UniProt Synonym Gene Names
UniProt Entry Name
VNN2_HUMAN
NCBI Summary for VNN2
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
UniProt Comments for VNN2
VNN2: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Belongs to the CN hydrolase family. BTD/VNN subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; EC 3.5.1.92
Chromosomal Location of Human Ortholog: 6q23-q24
Molecular Function: pantetheine hydrolase activity
Biological Process: biotin metabolic process; cell motility; central nervous system development; pantothenate metabolic process
Research Articles on VNN2
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Pathways associated with VNN2 cdna clone
Diseases associated with VNN2 cdna clone
Organs/Tissues associated with VNN2 cdna clone
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