BC044575
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,813 Da
NCBI Official Full Name
Homo sapiens tryptophanyl tRNA synthetase 2, mitochondrial, mRNA
NCBI Official Synonym Full Names
tryptophanyl tRNA synthetase 2, mitochondrial
NCBI Official Synonym Symbols
NCBI Protein Information
tryptophan--tRNA ligase, mitochondrial
UniProt Protein Name
Tryptophan--tRNA ligase, mitochondrial
UniProt Synonym Protein Names
(Mt)TrpRS; Tryptophanyl-tRNA synthetase; TrpRS
UniProt Synonym Gene Names
UniProt Entry Name
SYWM_HUMAN
NCBI Summary for WARS2
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for WARS2
WARS2: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Protein type: Ligase; EC 6.1.1.2; Translation; Amino Acid Metabolism - tryptophan; Mitochondrial
Chromosomal Location of Human Ortholog: 1p12
Cellular Component: mitochondrial matrix
Molecular Function: tryptophan-tRNA ligase activity
Biological Process: tRNA aminoacylation for protein translation
Research Articles on WARS2
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Pathways associated with WARS2 cdna clone
Organs/Tissues associated with WARS2 cdna clone
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