BC013377
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
393,367 Da
NCBI Official Full Name
Homo sapiens WD repeat and FYVE domain containing 3, mRNA
NCBI Official Synonym Full Names
WD repeat and FYVE domain containing 3
NCBI Protein Information
WD repeat and FYVE domain-containing protein 3
UniProt Protein Name
WD repeat and FYVE domain-containing protein 3
UniProt Synonym Protein Names
Autophagy-linked FYVE protein; Alfy
UniProt Synonym Gene Names
UniProt Entry Name
WDFY3_HUMAN
NCBI Summary for WDFY3
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
UniProt Comments for WDFY3
WDFY3: 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear envelope; Lipid-binding; Transferase; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 4q21.23
Cellular Component: autophagic vacuole; cytoplasm; extrinsic to membrane; inclusion body; nuclear envelope; PML body
Molecular Function: phosphatidylinositol binding; protein binding
Research Articles on WDFY3
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Diseases associated with WDFY3 cdna clone
Organs/Tissues associated with WDFY3 cdna clone
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