BC011874
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,801 Da
NCBI Official Full Name
Homo sapiens WD repeat domain 34, mRNA
NCBI Official Synonym Full Names
WD repeat domain 34
NCBI Official Synonym Symbols
DIC5; FAP133; SRTD11; bA216B9.3 [Similar Products]
NCBI Protein Information
WD repeat-containing protein 34
UniProt Protein Name
WD repeat-containing protein 34
UniProt Entry Name
WDR34_HUMAN
NCBI Summary for WDR34
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
UniProt Comments for WDR34
WDR34: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: axoneme; centriole; cytoplasm
Molecular Function: protein binding
Disease: Short-rib Thoracic Dysplasia 11 With Or Without Polydactyly
Research Articles on WDR34
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Diseases associated with WDR34 cdna clone
Organs/Tissues associated with WDR34 cdna clone
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