BC113467
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
121,725 Da
NCBI Official Full Name
Homo sapiens WD repeat domain 6, mRNA
NCBI Official Synonym Full Names
WD repeat domain 6
NCBI Protein Information
WD repeat-containing protein 6
UniProt Protein Name
WD repeat-containing protein 6
UniProt Entry Name
WDR6_HUMAN
NCBI Summary for WDR6
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
UniProt Comments for WDR6
WDR6: Enhances the STK11-induced cell growth suppression activity. Interacts with IRS4. Interacts with STK11.
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cytoplasm; signalosome
Molecular Function: protein binding
Biological Process: cell cycle arrest; negative regulation of autophagy; negative regulation of cell proliferation
Research Articles on WDR6
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Organs/Tissues associated with WDR6 cdna clone
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