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WWP1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1267912 WWP1 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WWP1, cDNA Clone

 Also Known As   

WWP1 cDNA Clone

 Product Gene Name   

WWP1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    602307
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of WWP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for WWP1. It may not necessarily be applicable to this product.
 NCBI GI #    23271280
 NCBI GeneID    11059
 NCBI Accession #    BC036065 [Other Products]
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 UniProt Secondary Accession #    O00307; Q5YLC1; Q96BP4 [Other Products]
 UniProt Related Accession #    Q9H0M0 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    Homo sapiens WW domain containing E3 ubiquitin protein ligase 1, mRNA
 NCBI Official Synonym Full Names    WW domain containing E3 ubiquitin protein ligase 1
 NCBI Official Symbol    WWP1 [Similar Products]
 NCBI Official Synonym Symbols   
AIP5; Tiul1; hSDRP1
[Similar Products]
 NCBI Protein Information    NEDD4-like E3 ubiquitin-protein ligase WWP1
 UniProt Protein Name    NEDD4-like E3 ubiquitin-protein ligase WWP1
 UniProt Synonym Protein Names   
Atrophin-1-interacting protein 5; AIP5; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
 Protein Family    NEDD4-like E3 ubiquitin-protein ligase
 UniProt Gene Name    WWP1 [Similar Products]
 UniProt Synonym Gene Names    AIP5; Tiul1 [Similar Products]
 UniProt Entry Name    WWP1_HUMAN
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 NCBI Summary for WWP1    WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WWP1    WWP1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ligase

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: entry of virus into host cell; negative regulation of transcription, DNA-dependent; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
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 Research Articles on WWP1    1. PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with WWP1 cdna cloneDiseases associated with WWP1 cdna clone
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Downregulation Of ERBB4 Signaling Pathway antibodies  Downregulation Of ERBB4 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >19 publications with WWP1 and Neoplasms
 Breast Neoplasms Antibodies  >14 publications with WWP1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >4 publications with WWP1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >3 publications with WWP1 and Cell Transformation, Neoplastic
 Death Antibodies  >2 publications with WWP1 and Death
 Inflammation Antibodies  >2 publications with WWP1 and Inflammation
 Necrosis Antibodies  >2 publications with WWP1 and Necrosis
 Brain Diseases Antibodies  >1 publications with WWP1 and Brain Diseases
 Atrophy Antibodies  >1 publications with WWP1 and Atrophy
 Growth Disorders Antibodies  >1 publications with WWP1 and Growth Disorders
Organs/Tissues associated with WWP1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >8 publications with WWP1 and Bone
 Prostate Antibodies  >7 publications with WWP1 and Prostate
 Muscle Antibodies  >5 publications with WWP1 and Muscle
 Lung Antibodies  >4 publications with WWP1 and Lung
 Bone Marrow Antibodies  >3 publications with WWP1 and Bone Marrow
 Blood Antibodies  >3 publications with WWP1 and Blood
 Nerve Antibodies  >2 publications with WWP1 and Nerve
 Connective Tissue Antibodies  >2 publications with WWP1 and Connective Tissue
 Brain Antibodies  >2 publications with WWP1 and Brain
 Heart Antibodies  >1 publications with WWP1 and Heart
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