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XPO4 cdna clone

Scan QR to view Datasheet Catalog #    MBS1272093 XPO4 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $1,130 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XPO4, cDNA Clone

 Also Known As   

XPO4 cDNA Clone

 Product Gene Name   

XPO4 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggtcaata atgaacaacg ccagcatgca gagcacatat tcttatcatt taggaaatca aaatcaccat ttgcagtttg caagcatatt ttggaaacta gtaaagtgga ctatgtcctc tttcaagctg ccacagccat aatggaagca gttgtccgag agtggattct cttggaaaaa ggtagcatcg agtctctgcg aacattcctt ttaacctatg tcttacaaag gcccaacctt caaaagtatg ttcgggaaca gattctacta gcagtagcag taattgtaaa aagaggatca ttagataaat caattgactg caaaagcatt tttcatgaag tcagccagtt gattagtagt ggcaatccca ctgtgcaaac tctggcctgt tctattctga ctgcgctatt gagtgaattt tcaagttcaa gtaaaactag caacattgga ttgagcatgg aattccatgg taactgcaaa agagtttttc aggaagaaga ccttcgtcag atcttcatgt taactgttga agttctgcag gagttcagca ggcgggaaaa cctcaatgct cagatgtctt cagtatttca gcgttacctt gcactcgcca atcaagtctt gagctggaac tttcttcctc caaatttggg cagacattat atagctatgt ttgaatcctc gcaaaatgtg ctgttgaagc caacagagtc ctggcgggag actcttctgg acagcagagt tatggagctt ttcttcacag tacatcgaaa aatcagagaa gattcagata tggcacaaga ttctctgcag tgccttgccc agttagcttc tcttcatgga cccatcttcc cagatgaagg atcacaagtt gattatctag cacacttcat tgagggatta ctgaatacta tcaatggaat tgaaatagaa gattctgaag ctgtggggat ctccagcatt atcagcaacc tgataaccgt gttcccacga aatgttttaa ctgccattcc aagtgaactt ttctcctcct ttgttaactg cctcacacac ctcacttgtt cttttgggcg aagtgctgca ttggaagaag tgcttgataa agatgacatg gtatacatgg aagcatatga taaattgttg gagtcctggt taactttggt tcaagatgac aaacatttcc ataaaggctt ttttacccaa catgcagttc aagttttcaa ttcctatatt cagtgccacc tagctgctcc agatggcaca agaaatttga ctgccaatgg tgtggcctct cgtgaggagg aagaaataag tgaacttcaa gaggatgatc gagaccagtt ttctgatcaa ctggccagtg taggaatgct aggaagaatt gctgcagaac actgtatacc tcttctgaca agtttattag aagaaagagt aacaagactc catggtcagt tacaacgaca tcagcaacag ttacttgctt caccgggttc aagcactgtt gacaacaaaa tgcttgatga tctctatgaa gatattcact ggcttatttt agttacaggc tacctcttag ctgatgatac tcagggagag actccgctaa tacctccaga aataatggaa tattccatta agcattcatc tgaagttgac attaatacaa cacttcaaat tttgggatct ccaggagaaa aggcttcttc catcccaggg tacaacagaa cagattctgt gattaggctg ttgtctgcca ttctcagagt ttcagaagtt gaatctcgag caataagagc agatctcact catctactaa gtccccagat gggcaaagat attgtttggt ttttaaaacg ctgggcaaag acttatctcc tggtggatga aaaactgtat gatcagataa gtctgccatt cagtacagcg ttcggagcag atacagaggg ttctcagtgg ataattggct acctcttaca aaaagtcatc agtaacctct cagtctggag tagtgagcag gaccttgcaa atgacactgt gcagctcctt gtcactttgg tggaaagaag agaaagggca aacttagtaa ttcaatgtga gaactggtgg aatttagcta agcagtttgc aagccgaagc ccacctctta atttcttgtc aagtcctgtg cagaggacat tgatgaaggc tctagtctta ggaggttttg cacatatgga cacagaaacc aaacagcagt attggacaga ggttcttcag ccacttcagc agcgattctt aagagtgata aaccaagaaa acttccagca gatgtgtcag caagaggaag tcaagcagga aatcactgcc acactagagg ccctgtgtgg cattgctgag gctacccaga ttgacaacgt agcaatcctg tttaattttt taatggactt ccttaccaat tgcattggat tgatggaagt ttacaagaat accccagaga ctgtcaatct cattatagaa gtttttgttg aagttgcaca taaacagata tgctatcttg gagagtccaa agctatgaac ttatatgaag cctgccttac tttgttgcaa gtgtattcta agaataattt agggcggcaa agaatagatg ttacagcaga agaagagcaa taccaagacc tgcttctcat tatggaactt cttactaacc tgctgtcaaa agaattcata gatttcagtg atacagatga agtgtttaga ggacatgagc caggtcaagc agcaaacaga tctgtgtcag cagcggatgt tgtgttgtat ggagtaaacc taattctgcc cttgatgtca caggatctct tgaagtttcc aaccctttgt aatcagtact acaaattaat cacatttatc tgtgagattt ttcctgaaaa aataccacag cttcctgagg atctgtttaa aagtctgatg tactccctag aattaggaat gacatcaatg agttcggagg tttgccagct ttgcctggag gccttgacac cgttagctga acagtgtgca aaagcacaag aaacagactc accacttttt ctagcaacac ggcactttct taagctggtt tttgatatgc tggttttgca aaagcacaac acagagatga ccactgcggc tggcgaagct ttctacacgt tggtgtgttt gcaccaggct gaatattctg aactggtcga aacattacta tcaagtcagc aagacccagt tatttaccag agattagcag atgccttcaa caagctcact gcaagcagca ctcctcctac gctggatcgg aagcagaaga tggccttctt aaagagttta gaagaattta tggcaaatgt tggtggtctc ctttgtgtaa aataa
 OMIM    611449
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 Vector    pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of XPO4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for XPO4. It may not necessarily be applicable to this product.
 NCBI GI #    111599358
 NCBI GeneID    64328
 NCBI Accession #    BC113571 [Other Products]
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 UniProt Secondary Accession #    Q5VUZ5; Q8N3V6; Q9H934 [Other Products]
 UniProt Related Accession #    Q9C0E2 [Other Products]
 Molecular Weight    130,139 Da
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 NCBI Official Full Name    Homo sapiens exportin 4, mRNA
 NCBI Official Synonym Full Names    exportin 4
 NCBI Official Symbol    XPO4 [Similar Products]
 NCBI Official Synonym Symbols   
exp4
[Similar Products]
 NCBI Protein Information    exportin-4
 UniProt Protein Name    Exportin-4
 Protein Family    Exportin
 UniProt Gene Name    XPO4 [Similar Products]
 UniProt Synonym Gene Names    KIAA1721; Exp4 [Similar Products]
 UniProt Entry Name    XPO4_HUMAN
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 NCBI Summary for XPO4    XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
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 UniProt Comments for XPO4    Exportin-4: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.

Protein type: Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 13q11

Cellular Component: cytoplasm; nuclear pore; nucleoplasm

Molecular Function: nuclear export signal receptor activity; protein binding; Ran GTPase binding

Biological Process: positive regulation of protein export from nucleus
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 Research Articles on XPO4    1. Knockdown of exportins 4, 5, and 7 altered thyroid hormone receptor shuttling dynamics, and when exportins 5 and 7 were overexpressed, TR distribution shifted toward the cytosol.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with XPO4 cdna clone
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >3 publications with XPO4 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with XPO4 and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with XPO4 and Liver Diseases
 Liver Neoplasms, Experimental Antibodies  >2 publications with XPO4 and Liver Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with XPO4 and Disease Models, Animal
 Fatty Liver Antibodies  >1 publications with XPO4 and Fatty Liver
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