BC113571
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
130,139 Da
NCBI Official Full Name
Homo sapiens exportin 4, mRNA
NCBI Official Synonym Full Names
exportin 4
NCBI Official Synonym Symbols
NCBI Protein Information
exportin-4
UniProt Protein Name
Exportin-4
UniProt Synonym Gene Names
UniProt Entry Name
XPO4_HUMAN
NCBI Summary for XPO4
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
UniProt Comments for XPO4
Exportin-4: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.
Protein type: Nuclear export; Karyopherin
Chromosomal Location of Human Ortholog: 13q11
Cellular Component: cytoplasm; nuclear pore; nucleoplasm
Molecular Function: nuclear export signal receptor activity; protein binding; Ran GTPase binding
Biological Process: positive regulation of protein export from nucleus
Research Articles on XPO4
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Diseases associated with XPO4 cdna clone
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