BC130304
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
127,394 Da
NCBI Official Full Name
Homo sapiens exportin 6, mRNA
NCBI Official Synonym Full Names
exportin 6
NCBI Protein Information
exportin-6
UniProt Protein Name
Exportin-6
UniProt Synonym Protein Names
Ran-binding protein 20
UniProt Synonym Gene Names
UniProt Entry Name
XPO6_HUMAN
NCBI Summary for XPO6
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
UniProt Comments for XPO6
Exportin-6: a protein of the exportin family. Exportins recruit cargo from the nucleoplasm in the presence of RAN-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled. Exportin 6 mediates nuclear export of profilin-actin complexes.
Protein type: Nuclear export; Karyopherin; Nuclear import
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytoplasm; nucleolus; nucleus; plasma membrane
Molecular Function: protein binding; protein transporter activity
Biological Process: protein export from nucleus
Research Articles on XPO6
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Diseases associated with XPO6 cdna clone
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