BC023593
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,477 Da
NCBI Official Full Name
Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1, mRNA
NCBI Official Synonym Full Names
X-ray repair cross complementing 1
NCBI Official Synonym Symbols
NCBI Protein Information
DNA repair protein XRCC1
UniProt Protein Name
DNA repair protein XRCC1
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 1
UniProt Entry Name
XRCC1_HUMAN
NCBI Summary for XRCC1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
UniProt Comments for XRCC1
XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA ligase activity; enzyme binding; protein binding
Biological Process: base-excision repair; base-excision repair, DNA ligation; double-strand break repair via homologous recombination; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair
Research Articles on XRCC1
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Pathways associated with XRCC1 cdna clone
Diseases associated with XRCC1 cdna clone
Organs/Tissues associated with XRCC1 cdna clone
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