BC012776
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,081 Da
NCBI Official Full Name
Homo sapiens XRCC6 binding protein 1, mRNA
NCBI Official Synonym Full Names
ATP23 metallopeptidase and ATP synthase assembly factor homolog
NCBI Protein Information
mitochondrial inner membrane protease ATP23 homolog
UniProt Protein Name
Mitochondrial inner membrane protease ATP23 homolog
UniProt Synonym Protein Names
Ku70-binding protein 3; XRCC6-binding protein 1
UniProt Entry Name
ATP23_HUMAN
NCBI Summary for XRCC6BP1
The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
UniProt Comments for XRCC6BP1
XRCC6BP1: Belongs to the peptidase M76 family.
Protein type: DNA repair, damage; Protease; EC 3.4.24.-
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component: intracellular membrane-bound organelle; plasma membrane
Molecular Function: DNA-dependent protein kinase activity
Biological Process: double-strand break repair via nonhomologous end joining
Research Articles on XRCC6BP1
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Diseases associated with XRCC6BP1 cdna clone
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