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ZIC3 cdna clone

Scan QR to view Datasheet Catalog #    MBS1266821 ZIC3 cdna clone
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 Product Name   

ZIC3, cDNA Clone

 Also Known As   

ZIC3 cDNA Clone

 Product Gene Name   

ZIC3 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    300265
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ZIC3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ZIC3. It may not necessarily be applicable to this product.
 NCBI GI #    109730454
 NCBI GeneID    7547
 NCBI Accession #    BC113393 [Other Products]
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 UniProt Secondary Accession #    Q14DE5; Q5JY75; B2CNW4 [Other Products]
 UniProt Related Accession #    O60481 [Other Products]
 Molecular Weight    50,045 Da
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 NCBI Official Full Name    Homo sapiens Zic family member 3 (odd-paired homolog, Drosophila), mRNA
 NCBI Official Synonym Full Names    Zic family member 3
 NCBI Official Symbol    ZIC3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    zinc finger protein ZIC 3
 UniProt Protein Name    Zinc finger protein ZIC 3
 UniProt Synonym Protein Names   
Zinc finger protein 203; Zinc finger protein of the cerebellum 3
 Protein Family    Zinc finger protein
 UniProt Gene Name    ZIC3 [Similar Products]
 UniProt Synonym Gene Names    ZNF203 [Similar Products]
 UniProt Entry Name    ZIC3_HUMAN
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 NCBI Summary for ZIC3    This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ZIC3    ZIC3: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Defects in ZIC3 are the cause of visceral heterotaxy X- linked type 1 (HTX1). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy X- linked type 1 include dextrocardia, corrected transposition of great arteries, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis, situs inversus viscerum, and asplenia and/or polysplenia. Defects in ZIC3 are a cause of VACTERL association X- linked with or without hydrocephalus (VACTERLX). A syndrome characterized by vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: Xq26.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: determination of left/right symmetry; heart looping; lung development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; somatic stem cell maintenance

Disease: Heterotaxy, Visceral, 1, X-linked; Vacterl Association, X-linked, With Or Without Hydrocephalus
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 Research Articles on ZIC3    1. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with ZIC3 cdna cloneOrgans/Tissues associated with ZIC3 cdna clone
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >35 publications with ZIC3 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >20 publications with ZIC3 and Heart Defects, Congenital
 Neural Tube Defects Antibodies  >15 publications with ZIC3 and Neural Tube Defects
 Nervous System Diseases Antibodies  >15 publications with ZIC3 and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >12 publications with ZIC3 and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >6 publications with ZIC3 and Disease Models, Animal
 Dextrocardia Antibodies  >5 publications with ZIC3 and Dextrocardia
 Craniofacial Abnormalities Antibodies  >4 publications with ZIC3 and Craniofacial Abnormalities
 Neoplasms Antibodies  >3 publications with ZIC3 and Neoplasms
 Heterotaxy, visceral, X-linked Antibodies  >2 publications with ZIC3 and Heterotaxy, visceral, X-linked
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with ZIC3 and Brain
 Embryonic Tissue Antibodies  >23 publications with ZIC3 and Embryonic Tissue
 Eye Antibodies  >7 publications with ZIC3 and Eye
 Muscle Antibodies  >4 publications with ZIC3 and Muscle
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