NP_036822.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,655 Da
NCBI Official Full Name
phosphatidylcholine translocator ABCB4
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 4
NCBI Official Synonym Symbols
NCBI Protein Information
phosphatidylcholine translocator ABCB4
UniProt Protein Name
Phosphatidylcholine translocator ABCB4
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4
NCBI Summary for ABCB4
energy-dependent efflux pump; may be involved in changes in bile formation in response to diabetes [RGD, Feb 2006]
UniProt Comments for ABCB4
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.
Research Articles on ABCB4
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Pathways associated with ABCB4 shrna
Diseases associated with ABCB4 shrna
Organs/Tissues associated with ABCB4 shrna
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