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ACER1 shrna

Scan QR to view Datasheet Catalog #    MBS8264879 ACER1 shrna
Unit / Price
0.15 mg  /  $540 +1 FREE 8GB USB
0.3 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACER1, shRNA

 Also Known As   

ACER1 shRNA Plasmid (Human)

 Product Synonym Names    ASAH3; Alkaline ceramidase 1; AlkCDase 1; Alkaline CDase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
 Product Gene Name   

ACER1 shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF347024 mRNA
 3D Structure    ModBase 3D Structure for Q8TDN7
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 Host    E Coli
 Species Reactivity    Human
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 Specificity    ACER1 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down human ACER1 gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of ACER1 shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ACER1 shrna

   shRNA Plasmid to inhibit ACER1 expression by RNA interference
 Applications Tested/Suitable for ACER1 shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ACER1. It may not necessarily be applicable to this product.
 NCBI GI #    19424128
 NCBI GeneID    125981
 NCBI Accession #    NP_597999.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_133492.2 [Other Products]
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 UniProt Primary Accession #    Q8TDN7 [Other Products]
 UniProt Related Accession #    Q8TDN7 [Other Products]
 Molecular Weight    31,095 Da
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 NCBI Official Full Name    alkaline ceramidase 1
 NCBI Official Synonym Full Names    alkaline ceramidase 1
 NCBI Official Symbol    ACER1 [Similar Products]
 NCBI Official Synonym Symbols   
ASAH3; ALKCDase1
[Similar Products]
 NCBI Protein Information    alkaline ceramidase 1
 UniProt Protein Name    Alkaline ceramidase 1
 UniProt Synonym Protein Names   
Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
 Protein Family    Alkaline ceramidase
 UniProt Gene Name    ACER1 [Similar Products]
 UniProt Synonym Gene Names    ASAH3; AlkCDase 1; Alkaline CDase 1 [Similar Products]
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 NCBI Summary for ACER1    Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
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 UniProt Comments for ACER1    Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids ().
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 Research Articles on ACER1    1. upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of keratinocytes by generating sphingosine and its phosphate
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACER1 shrnaDiseases associated with ACER1 shrna
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Signaling Pathway antibodies  Sphingolipid Signaling Pathway Diagram
 Sphingolipid Signaling Pathway antibodies  Sphingolipid Signaling Pathway Diagram
 Sphingosine Biosynthesis Pathway antibodies  Sphingosine Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1 publications with ACER1 and Cardiovascular Diseases
 Mental Disorders Antibodies  >1 publications with ACER1 and Mental Disorders
 Vascular Diseases Antibodies  >1 publications with ACER1 and Vascular Diseases
 Fatty Liver Antibodies  >1 publications with ACER1 and Fatty Liver
Organs/Tissues associated with ACER1 shrna
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with ACER1 and Skin
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