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ARIH1 shrna

Scan QR to view Datasheet Catalog #    MBS8258574 ARIH1 shrna
Unit / Price
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

ARIH1 shRNA Plasmid (Human)

 Product Synonym Names    ARI; MOP6; UBCH7BP; E3 ubiquitin-protein ligase ARIH1; H7-AP2; HHARI; Monocyte protein 6; MOP-6; Protein ariadne-1 homolog; ARI-1; UbcH7-binding protein; UbcM4-interacting protein; Ubiquitin-conjugating enzyme E2-binding protein 1
 Product Gene Name   

ARIH1 shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AJ243190 mRNA
 3D Structure    ModBase 3D Structure for Q9Y4X5
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 Host    E Coli
 Species Reactivity    Human
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 Specificity    ARIH1 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down human ARIH1 gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of ARIH1 shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ARIH1 shrna

   shRNA Plasmid to inhibit ARIH1 expression by RNA interference
 Applications Tested/Suitable for ARIH1 shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ARIH1. It may not necessarily be applicable to this product.
 NCBI GI #    187761373
 NCBI GeneID    25820
 NCBI Accession #    NP_005735.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005744.3 [Other Products]
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 UniProt Primary Accession #    Q9Y4X5 [Other Products]
 UniProt Secondary Accession #    O76026; Q9H3T6; Q9UEN0; Q9UP39; B2R6U3 [Other Products]
 UniProt Related Accession #    Q9Y4X5 [Other Products]
 Molecular Weight    64,118 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase ARIH1
 NCBI Official Synonym Full Names    ariadne RBR E3 ubiquitin protein ligase 1
 NCBI Official Symbol    ARIH1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase ARIH1
 UniProt Protein Name    E3 ubiquitin-protein ligase ARIH1
 UniProt Synonym Protein Names   
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    ARIH1 [Similar Products]
 UniProt Synonym Gene Names    ARI-1 [Similar Products]
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 UniProt Comments for ARIH1    E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).
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 Research Articles on ARIH1    1. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ARIH1 shrnaPathways associated with ARIH1 shrna
 Reference Product  PubMed Publications
 UBE2L3 shrna  >5 publications with ARIH1 and UBE2L3
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
Diseases associated with ARIH1 shrnaOrgans/Tissues associated with ARIH1 shrna
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with ARIH1 and Nervous System Diseases
 Movement Disorders Antibodies  >3 publications with ARIH1 and Movement Disorders
 Brain Diseases Antibodies  >3 publications with ARIH1 and Brain Diseases
 Mental Disorders Antibodies  >2 publications with ARIH1 and Mental Disorders
 Death Antibodies  >1 publications with ARIH1 and Death
 Carcinoma, Hepatocellular Antibodies  >1 publications with ARIH1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with ARIH1 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with ARIH1 and Liver Diseases
 Weight Loss Antibodies  >1 publications with ARIH1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with ARIH1 and Brain
 Liver Antibodies  >1 publications with ARIH1 and Liver
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