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DAXX shrna

Scan QR to view Datasheet Catalog #    MBS8270002 DAXX shrna
Unit / Price
0.15 mg  /  $540 +1 FREE 8GB USB
0.3 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAXX, shRNA

 Also Known As   

DAXX shRNA Plasmid (Mouse)

 Product Synonym Names    Death domain-associated protein 6; Daxx
 Product Gene Name   

DAXX shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O35613
 Host    E Coli
 Species Reactivity    Mouse
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 Specificity    DAXX shRNA Plasmid (Mouse) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down mouse DAXX gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of DAXX shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for DAXX shrna

   shRNA Plasmid to inhibit DAXX expression by RNA interference
 Applications Tested/Suitable for DAXX shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for DAXX. It may not necessarily be applicable to this product.
 NCBI GI #    315013583
 NCBI GeneID    13163
 NCBI Accession #    NP_001186662.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199733.1 [Other Products]
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 UniProt Primary Accession #    O35613 [Other Products]
 UniProt Secondary Accession #    Q9QWT8; Q9QWV3 [Other Products]
 UniProt Related Accession #    O35613 [Other Products]
 Molecular Weight    81,489 Da
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 NCBI Official Full Name    death domain-associated protein 6
 NCBI Official Synonym Full Names    Fas death domain-associated protein
 NCBI Official Symbol    Daxx [Similar Products]
 NCBI Protein Information    death domain-associated protein 6
 UniProt Protein Name    Death domain-associated protein 6
 UniProt Synonym Protein Names   
Daxx
 Protein Family    Death domain-associated protein
 UniProt Gene Name    Daxx [Similar Products]
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 UniProt Comments for DAXX    Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response ().
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 Research Articles on DAXX    1. Daxx and Atrx safeguard the genome by silencing repetitive elements when DNA methylation levels are low.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DAXX shrnaPathways associated with DAXX shrna
 Reference Product  PubMed Publications
 Dmap1 shrna  >2 publications with DAXX and Dmap1
 Crebbp shrna  >1 publications with DAXX and Crebbp
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with DAXX shrnaOrgans/Tissues associated with DAXX shrna
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >67 publications with DAXX and Neoplasms
 Necrosis Antibodies  >22 publications with DAXX and Necrosis
 Leukemia, Myeloid Antibodies  >20 publications with DAXX and Leukemia, Myeloid
 Carcinoma Antibodies  >16 publications with DAXX and Carcinoma
 Vascular Diseases Antibodies  >10 publications with DAXX and Vascular Diseases
 Adenocarcinoma Antibodies  >10 publications with DAXX and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >10 publications with DAXX and Cardiovascular Diseases
 Prostatic Diseases Antibodies  >8 publications with DAXX and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >8 publications with DAXX and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >7 publications with DAXX and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with DAXX and Blood
 Brain Antibodies  >22 publications with DAXX and Brain
 Kidney Antibodies  >8 publications with DAXX and Kidney
 Liver Antibodies  >8 publications with DAXX and Liver
 Heart Antibodies  >7 publications with DAXX and Heart
 Bone Marrow Antibodies  >5 publications with DAXX and Bone Marrow
 Testis Antibodies  >4 publications with DAXX and Testis
 Spleen Antibodies  >3 publications with DAXX and Spleen
 Eye Antibodies  >3 publications with DAXX and Eye
 Lung Antibodies  >3 publications with DAXX and Lung
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