NP_001103374.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
88,708 Da
NCBI Official Full Name
fibroblast growth factor receptor 4
NCBI Official Synonym Full Names
fibroblast growth factor receptor 4
NCBI Protein Information
fibroblast growth factor receptor 4
UniProt Protein Name
Fibroblast growth factor receptor 4
UniProt Synonym Protein Names
CD_antigen: CD334
UniProt Synonym Gene Names
NCBI Summary for FGFR4
fibroblast growth factor receptor subtype expressed in lung and kidney [RGD, Feb 2006]
UniProt Comments for FGFR4
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 ().
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Products associated with FGFR4 shrna
Pathways associated with FGFR4 shrna
Diseases associated with FGFR4 shrna
Organs/Tissues associated with FGFR4 shrna
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