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LRP5 shrna

Scan QR to view Datasheet Catalog #    MBS8252787 LRP5 shrna
Unit / Price
0.15 mg  /  $540 +1 FREE 8GB USB
0.3 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LRP5, shRNA

 Also Known As   

LRP5 shRNA Plasmid (Human)

 Product Synonym Names    LR3; LRP7; Low-density lipoprotein receptor-related protein 5; LRP-5
 Product Gene Name   

LRP5 shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF077820 mRNA
 3D Structure    ModBase 3D Structure for O75197
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 Host    E Coli
 Species Reactivity    Human
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 Specificity    LRP5 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down human LRP5 gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of LRP5 shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for LRP5 shrna

   shRNA Plasmid to inhibit LRP5 expression by RNA interference
 Applications Tested/Suitable for LRP5 shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for LRP5. It may not necessarily be applicable to this product.
 NCBI GI #    631790829
 NCBI GeneID    4041
 NCBI Accession #    NP_001278831.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291902.1 [Other Products]
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 UniProt Primary Accession #    O75197 [Other Products]
 UniProt Secondary Accession #    Q96TD6; Q9UES7; Q9UP66 [Other Products]
 UniProt Related Accession #    O75197 [Other Products]
 Molecular Weight    179,145 Da
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 NCBI Official Full Name    low-density lipoprotein receptor-related protein 5 isoform 2
 NCBI Official Synonym Full Names    LDL receptor related protein 5
 NCBI Official Symbol    LRP5 [Similar Products]
 NCBI Official Synonym Symbols   
HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor-related protein 5
 UniProt Protein Name    Low-density lipoprotein receptor-related protein 5
 Protein Family    Low-density lipoprotein receptor-related protein
 UniProt Gene Name    LRP5 [Similar Products]
 UniProt Synonym Gene Names    LR3; LRP7; LRP-5 [Similar Products]
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 NCBI Summary for LRP5    This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for LRP5    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (). Required for posterior patterning of the epiblast during gastrulation ().
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 Research Articles on LRP5    1. wild-type and all five mutant LRP5 proteins were assayed for the ability to activate the Norrin/beta-catenin pathway by established luciferase reporter assays, and all mutants failed to activate the pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LRP5 shrnaPathways associated with LRP5 shrna
 Reference Product  PubMed Publications
 DKK1 shrna  >134 publications with LRP5 and DKK1
 WNT3A shrna  >113 publications with LRP5 and WNT3A
 WNT1 shrna  >54 publications with LRP5 and WNT1
 WNT5A shrna  >50 publications with LRP5 and WNT5A
 FZD1 shrna  >18 publications with LRP5 and FZD1
 AXIN1 shrna  >14 publications with LRP5 and AXIN1
 DVL2 shrna  >12 publications with LRP5 and DVL2
 DVL1 shrna  >6 publications with LRP5 and DVL1
 DVL3 shrna  >4 publications with LRP5 and DVL3
 CDH2 shrna  >1 publications with LRP5 and CDH2
 Products by Pathway  Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies  Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies  Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
 Primary Focal Segmental Glomerulosclerosis FSGS Pathway antibodies  Primary Focal Segmental Glomerulosclerosis FSGS Pathway Diagram
Diseases associated with LRP5 shrnaOrgans/Tissues associated with LRP5 shrna
 Disease Name  Pubmed Publications
 Osteoporosis Antibodies  >295 publications with LRP5 and Osteoporosis
 Fractures, Bone Antibodies  >88 publications with LRP5 and Fractures, Bone
 Osteoporosis-pseudoglioma syndrome Antibodies  >56 publications with LRP5 and Osteoporosis-pseudoglioma syndrome
 Inflammation Antibodies  >25 publications with LRP5 and Inflammation
 Necrosis Antibodies  >19 publications with LRP5 and Necrosis
 Exudative Vitreoretinopathy 4 Antibodies  >18 publications with LRP5 and Exudative Vitreoretinopathy 4
 Heart Diseases Antibodies  >17 publications with LRP5 and Heart Diseases
 Fibrosis Antibodies  >15 publications with LRP5 and Fibrosis
 Vitreoretinopathy, Proliferative Antibodies  >14 publications with LRP5 and Vitreoretinopathy, Proliferative
 Lung Diseases Antibodies  >14 publications with LRP5 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >546 publications with LRP5 and Bone
 Connective Tissue Antibodies  >130 publications with LRP5 and Connective Tissue
 Eye Antibodies  >70 publications with LRP5 and Eye
 Vascular Antibodies  >59 publications with LRP5 and Vascular
 Embryonic Tissue Antibodies  >40 publications with LRP5 and Embryonic Tissue
 Brain Antibodies  >31 publications with LRP5 and Brain
 Parathyroid Antibodies  >29 publications with LRP5 and Parathyroid
 Muscle Antibodies  >28 publications with LRP5 and Muscle
 Liver Antibodies  >27 publications with LRP5 and Liver
 Lung Antibodies  >24 publications with LRP5 and Lung
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