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MC4R shrna

Scan QR to view Datasheet Catalog #    MBS8285237 MC4R shrna
Unit / Price
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

MC4R shRNA Plasmid (Rat)

 Product Synonym Names    Melanocortin receptor 4; MC4-R
 Product Gene Name   

MC4R shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P70596
 Host    E Coli
 Species Reactivity    Rat
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 Specificity    MC4R shRNA Plasmid (Rat) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down rat MC4R gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of MC4R shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MC4R shrna

   shRNA Plasmid to inhibit MC4R expression by RNA interference
 Applications Tested/Suitable for MC4R shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.
 NCBI GI #    25742776
 NCBI GeneID    25635
 NCBI Accession #    NP_037231.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013099.3 [Other Products]
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 UniProt Primary Accession #    P70596 [Other Products]
 UniProt Related Accession #    P70596 [Other Products]
 Molecular Weight    36,887 Da
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 NCBI Official Full Name    melanocortin receptor 4
 NCBI Official Synonym Full Names    melanocortin 4 receptor
 NCBI Official Symbol    Mc4r [Similar Products]
 NCBI Protein Information    melanocortin receptor 4
 UniProt Protein Name    Melanocortin receptor 4
 Protein Family    Melanocortin receptor
 UniProt Gene Name    Mc4r [Similar Products]
 UniProt Synonym Gene Names    MC4-R [Similar Products]
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 NCBI Summary for MC4R    receptor involved in maintaining energy homeostasis [RGD, Feb 2006]
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 UniProt Comments for MC4R    Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
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 Research Articles on MC4R    1. MC4R is predominantly expressed in hepatocytes and upregulated during rat liver regeneration after hepatectomy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MC4R shrnaDiseases associated with MC4R shrna
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Disease Name  Pubmed Publications
 Obesity Antibodies  >439 publications with MC4R and Obesity
 Body Weight Antibodies  >422 publications with MC4R and Body Weight
 Weight Loss Antibodies  >55 publications with MC4R and Weight Loss
 Insulin Resistance Antibodies  >37 publications with MC4R and Insulin Resistance
 Diabetes Mellitus, Type 2 Antibodies  >27 publications with MC4R and Diabetes Mellitus, Type 2
 Hypertension Antibodies  >26 publications with MC4R and Hypertension
 Nervous System Diseases Antibodies  >20 publications with MC4R and Nervous System Diseases
 Inflammation Antibodies  >17 publications with MC4R and Inflammation
 Brain Diseases Antibodies  >15 publications with MC4R and Brain Diseases
 Fatty Liver Antibodies  >8 publications with MC4R and Fatty Liver
Organs/Tissues associated with MC4R shrna
 Organ/Tissue Name  Pubmed Publications
 Dorsal Root Ganglion Antibodies  >4 publications with MC4R and Dorsal Root Ganglion
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