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MEGF10 shrna

Scan QR to view Datasheet Catalog #    MBS8263546 MEGF10 shrna
Unit / Price
0.15 mg  /  $540 +1 FREE 8GB USB
0.3 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MEGF10, shRNA

 Also Known As   

MEGF10 shRNA Plasmid (Human)

 Product Synonym Names    KIAA1780; Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10
 Product Gene Name   

MEGF10 shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB058676 mRNA
 3D Structure    ModBase 3D Structure for Q96KG7
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 Host    E Coli
 Species Reactivity    Human
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 Specificity    MEGF10 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down human MEGF10 gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of MEGF10 shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MEGF10 shrna

   shRNA Plasmid to inhibit MEGF10 expression by RNA interference
 Applications Tested/Suitable for MEGF10 shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for MEGF10. It may not necessarily be applicable to this product.
 NCBI GI #    375065830
 NCBI GeneID    84466
 NCBI Accession #    NP_001243474.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256545.1 [Other Products]
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 UniProt Primary Accession #    Q96KG7 [Other Products]
 UniProt Secondary Accession #    Q68DE5; Q8WUL3 [Other Products]
 UniProt Related Accession #    Q96KG7 [Other Products]
 Molecular Weight    60,797 Da
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 NCBI Official Full Name    multiple epidermal growth factor-like domains protein 10 isoform a
 NCBI Official Synonym Full Names    multiple EGF like domains 10
 NCBI Official Symbol    MEGF10 [Similar Products]
 NCBI Official Synonym Symbols   
EMARDD
[Similar Products]
 NCBI Protein Information    multiple epidermal growth factor-like domains protein 10
 UniProt Protein Name    Multiple epidermal growth factor-like domains protein 10
 Protein Family    Multiple epidermal growth factor-like domains protein
 UniProt Gene Name    MEGF10 [Similar Products]
 UniProt Synonym Gene Names    KIAA1780; Multiple EGF-like domains protein 10 [Similar Products]
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 NCBI Summary for MEGF10    This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
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 UniProt Comments for MEGF10    Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation probably through regulation of the notch signaling pathway.
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 Research Articles on MEGF10    1. results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with MEGF10 shrnaOrgans/Tissues associated with MEGF10 shrna
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with MEGF10 and Brain Diseases
 Movement Disorders Antibodies  >1 publications with MEGF10 and Movement Disorders
 Lung Diseases Antibodies  >1 publications with MEGF10 and Lung Diseases
 Respiration Disorders Antibodies  >1 publications with MEGF10 and Respiration Disorders
 Infant, Newborn, Diseases Antibodies  >1 publications with MEGF10 and Infant, Newborn, Diseases
 Inflammation Antibodies  >1 publications with MEGF10 and Inflammation
 Muscular Diseases Antibodies  >1 publications with MEGF10 and Muscular Diseases
 Deglutition Disorders Antibodies  >1 publications with MEGF10 and Deglutition Disorders
 Respiratory Distress Syndrome, Newborn Antibodies  >1 publications with MEGF10 and Respiratory Distress Syndrome, Newborn
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with MEGF10 and Brain
 Muscle Antibodies  >3 publications with MEGF10 and Muscle
 Nerve Antibodies  >2 publications with MEGF10 and Nerve
 Blood Antibodies  >2 publications with MEGF10 and Blood
 Bone Antibodies  >1 publications with MEGF10 and Bone
 Eye Antibodies  >1 publications with MEGF10 and Eye
 Kidney Antibodies  >1 publications with MEGF10 and Kidney
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