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NSMCE1 shrna

Scan QR to view Datasheet Catalog #    MBS8266258 NSMCE1 shrna
Unit / Price
  DISCONTINUED
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NSMCE1, shRNA

 Also Known As   

NSMCE1 shRNA Plasmid (Human)

 Product Synonym Names    Non-structural maintenance of chromosomes element 1 homolog; Non-SMC element 1 homolog
 Product Gene Name   

NSMCE1 shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF161451 mRNA
 3D Structure    ModBase 3D Structure for Q8WV22
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 Host    E Coli
 Species Reactivity    Human
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 Specificity    NSMCE1 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down human NSMCE1 gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of NSMCE1 shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NSMCE1 shrna

   shRNA Plasmid to inhibit NSMCE1 expression by RNA interference
 Applications Tested/Suitable for NSMCE1 shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for NSMCE1. It may not necessarily be applicable to this product.
 NCBI GI #    94721324
 NCBI GeneID    197370
 NCBI Accession #    NP_659547.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_145080.3 [Other Products]
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 UniProt Primary Accession #    Q8WV22 [Other Products]
 UniProt Secondary Accession #    Q9P045; Q9P049; D3DWF6 [Other Products]
 UniProt Related Accession #    Q8WV22 [Other Products]
 Molecular Weight    30,855 Da
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 NCBI Official Full Name    non-structural maintenance of chromosomes element 1 homolog
 NCBI Official Synonym Full Names    NSE1 homolog, SMC5-SMC6 complex component
 NCBI Official Symbol    NSMCE1 [Similar Products]
 NCBI Official Synonym Symbols   
NSE1
[Similar Products]
 NCBI Protein Information    non-structural maintenance of chromosomes element 1 homolog
 UniProt Protein Name    Non-structural maintenance of chromosomes element 1 homolog
 UniProt Gene Name    NSMCE1 [Similar Products]
 UniProt Synonym Gene Names    Non-SMC element 1 homolog [Similar Products]
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 UniProt Comments for NSMCE1    Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NSMCE1 shrna
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies  SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
 SUMOylation Pathway antibodies  SUMOylation Pathway Diagram
 SUMOylation Of DNA Damage Response And Repair Proteins Pathway antibodies  SUMOylation Of DNA Damage Response And Repair Proteins Pathway Diagram
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