NP_001273672.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
50,575 Da
NCBI Official Full Name
protein kinase C and casein kinase substrate in neurons protein 1
NCBI Official Synonym Full Names
protein kinase C and casein kinase substrate in neurons 1
NCBI Official Synonym Symbols
H74; syndapin; mKIAA1379; A830061D09Rik [Similar Products]
NCBI Protein Information
protein kinase C and casein kinase substrate in neurons protein 1
UniProt Protein Name
Protein kinase C and casein kinase substrate in neurons protein 1
UniProt Synonym Protein Names
Syndapin-1
UniProt Synonym Gene Names
UniProt Comments for PACSIN1
Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.
Research Articles on PACSIN1
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Products associated with PACSIN1 shrna
Diseases associated with PACSIN1 shrna
Organs/Tissues associated with PACSIN1 shrna
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