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PLCD4 shrna

Scan QR to view Datasheet Catalog #    MBS8272146 PLCD4 shrna
Unit / Price
0.15 mg  /  $540 +1 FREE 8GB USB
0.3 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLCD4, shRNA

 Also Known As   

PLCD4 shRNA Plasmid (Mouse)

 Product Synonym Names    PLCD; 1-phosphatidylinositol 4.5-bisphosphate phosphodiesterase delta-4; Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
 Product Gene Name   

PLCD4 shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8K3R3
 Host    E Coli
 Species Reactivity    Mouse
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 Specificity    PLCD4 shRNA Plasmid (Mouse) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down mouse PLCD4 gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of PLCD4 shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PLCD4 shrna

   shRNA Plasmid to inhibit PLCD4 expression by RNA interference
 Applications Tested/Suitable for PLCD4 shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for PLCD4. It may not necessarily be applicable to this product.
 NCBI GI #    125347158
 NCBI GeneID    18802
 NCBI Accession #    NP_001074925.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081456.1 [Other Products]
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 UniProt Primary Accession #    Q8K3R3 [Other Products]
 UniProt Secondary Accession #    Q3USN9; Q6NZF7; Q8CAB1; Q9CUC1 [Other Products]
 UniProt Related Accession #    Q8K3R3 [Other Products]
 Molecular Weight    57,480 Da
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 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1
 NCBI Official Synonym Full Names    phospholipase C, delta 4
 NCBI Official Symbol    Plcd4 [Similar Products]
 NCBI Official Synonym Symbols   
4921507K24Rik
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
 UniProt Synonym Protein Names   
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
 Protein Family    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
 UniProt Gene Name    Plcd4 [Similar Products]
 UniProt Synonym Gene Names    Plcd; PLC-delta-4 [Similar Products]
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 UniProt Comments for PLCD4    Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
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 Research Articles on PLCD4    1. These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PLCD4 shrnaDiseases associated with PLCD4 shrna
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 PIP Metabolism Pathway antibodies  PIP Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Disease Name  Pubmed Publications
 Pancreatic Neoplasms Antibodies  >1 publications with PLCD4 and Pancreatic Neoplasms
Organs/Tissues associated with PLCD4 shrna
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with PLCD4 and Testis
 Pancreas Antibodies  >1 publications with PLCD4 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with PLCD4 and Embryonic Tissue
 Brain Antibodies  >1 publications with PLCD4 and Brain
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