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WWOX shrna

Scan QR to view Datasheet Catalog #    MBS8279082 WWOX shrna
Unit / Price
  DISCONTINUED
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WWOX, shRNA

 Also Known As   

WWOX shRNA Plasmid (Mouse)

 Product Synonym Names    WOX1; WW domain-containing oxidoreductase
 Product Gene Name   

WWOX shrna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q91WL8
 Host    E Coli
 Species Reactivity    Mouse
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 Specificity    WWOX shRNA Plasmid (Mouse) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
 Form/Format    Lyophilized Powder
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 Quality Control    The sequence of shRNA is guaranteed by sequencing.
 Directions for Use    Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
 Components    We offer 3 different plasmids which knock down mouse WWOX gene specifically. Each vial contains 50 ug of lyophilized shRNA.
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 Preparation and Storage    Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
 Other Notes    Small volumes of WWOX shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for WWOX shrna

   shRNA Plasmid to inhibit WWOX expression by RNA interference
 Applications Tested/Suitable for WWOX shrna   

RNA interference (RNAi)

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NCBI/Uniprot data below describe general gene information for WWOX. It may not necessarily be applicable to this product.
 NCBI GI #    31980962
 NCBI GeneID    80707
 NCBI Accession #    NP_062519.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019573.3 [Other Products]
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 UniProt Primary Accession #    Q91WL8 [Other Products]
 UniProt Secondary Accession #    Q8C8J6; Q920Y2; Q9D2B3; Q9D339; Q9JLF5 [Other Products]
 UniProt Related Accession #    Q91WL8 [Other Products]
 Molecular Weight    41,457 Da
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 NCBI Official Full Name    WW domain-containing oxidoreductase
 NCBI Official Synonym Full Names    WW domain-containing oxidoreductase
 NCBI Official Symbol    Wwox [Similar Products]
 NCBI Official Synonym Symbols   
WOX1; 5330426P09Rik; 9030416C10Rik
[Similar Products]
 NCBI Protein Information    WW domain-containing oxidoreductase
 UniProt Protein Name    WW domain-containing oxidoreductase
 Protein Family    WW domain-containing oxidoreductase
 UniProt Gene Name    Wwox [Similar Products]
 UniProt Synonym Gene Names    Wox1 [Similar Products]
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 UniProt Comments for WWOX    Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development.
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 Research Articles on WWOX    1. Brca1-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with WWOX shrnaDiseases associated with WWOX shrna
 Products by Pathway  Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By ERBB4 Pathway antibodies  Signaling By ERBB4 Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >87 publications with WWOX and Carcinoma
 Breast Neoplasms Antibodies  >51 publications with WWOX and Breast Neoplasms
 Lung Neoplasms Antibodies  >30 publications with WWOX and Lung Neoplasms
 Chromosome Aberrations Antibodies  >28 publications with WWOX and Chromosome Aberrations
 Ovarian Neoplasms Antibodies  >26 publications with WWOX and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >20 publications with WWOX and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >19 publications with WWOX and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >17 publications with WWOX and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >16 publications with WWOX and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >16 publications with WWOX and Carcinoma, Squamous Cell
Organs/Tissues associated with WWOX shrna
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >70 publications with WWOX and Other
 Lung Antibodies  >35 publications with WWOX and Lung
 Bone Antibodies  >22 publications with WWOX and Bone
 Brain Antibodies  >21 publications with WWOX and Brain
 Liver Antibodies  >17 publications with WWOX and Liver
 Blood Antibodies  >16 publications with WWOX and Blood
 Ovary Antibodies  >8 publications with WWOX and Ovary
 Kidney Antibodies  >8 publications with WWOX and Kidney
 Bladder Antibodies  >6 publications with WWOX and Bladder
 Testis Antibodies  >5 publications with WWOX and Testis
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