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A4GALT sirna

Scan QR to view Datasheet Catalog #    MBS8201396 A4GALT sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   

A4GALT siRNA (Mouse)

 Product Synonym Names    Lactosylceramide 4-alpha-galactosyltransferase; Alpha-1.4-N-acetylglucosaminyltransferase; Alpha-1.4-galactosyltransferase; Alpha4Gal-T1; Globotriaosylceramide synthase; Gb3 synthase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
 Product Gene Name   

A4GALT sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q67BJ4
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    A4GALT siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse A4GALT gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of A4GALT sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for A4GALT sirna

   siRNA to inhibit A4GALT expression using RNA interference
 Applications Tested/Suitable for A4GALT sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for A4GALT. It may not necessarily be applicable to this product.
 NCBI GI #    51921295
 NCBI GeneID    239559
 NCBI Accession #    NP_001004150.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001004150.3 [Other Products]
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 UniProt Primary Accession #    Q67BJ4 [Other Products]
 UniProt Related Accession #    Q67BJ4 [Other Products]
 Molecular Weight    41,366 Da
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 NCBI Official Full Name    lactosylceramide 4-alpha-galactosyltransferase
 NCBI Official Synonym Full Names    alpha 1,4-galactosyltransferase
 NCBI Official Symbol    A4galt [Similar Products]
 NCBI Protein Information    lactosylceramide 4-alpha-galactosyltransferase
 UniProt Protein Name    Lactosylceramide 4-alpha-galactosyltransferase
 UniProt Synonym Protein Names   
Alpha-1,4-N-acetylglucosaminyltransferase; Alpha-1,4-galactosyltransferase; Alpha4Gal-T1; Globotriaosylceramide synthase; Gb3 synthase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
 Protein Family    Lactosylceramide 4-alpha-galactosyltransferase
 UniProt Gene Name    A4galt [Similar Products]
 UniProt Synonym Gene Names    Gb3 synthase [Similar Products]
 UniProt Entry Name    A4GAT_MOUSE
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 NCBI Summary for A4GALT    The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
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 UniProt Comments for A4GALT    A4GALT: Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. Belongs to the glycosyltransferase 32 family.

Protein type: Transferase; EC; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - globo series

Cellular Component: Golgi apparatus; membrane; integral to membrane

Molecular Function: transferase activity; toxin binding; transferase activity, transferring glycosyl groups; galactosyltransferase activity; lactosylceramide 4-alpha-galactosyltransferase activity

Biological Process: globoside biosynthetic process; plasma membrane organization and biogenesis; lipid metabolic process
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 Research Articles on A4GALT    1. Verification of the function of Gb3 in the pathogenesis of hemolytic-uremic syndrome as the cellular receptor responsible for cytotoxicity caused by verotoxin (VT) elaborated by Shigella and certain strains of E.coli.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with A4GALT sirnaPathways associated with A4GALT sirna
 Reference Product  PubMed Publications
 B3galnt1 sirna  >1 publications with A4GALT and B3galnt1
 Products by Pathway  Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway antibodies  Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway Diagram
 Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway antibodies  Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with A4GALT sirnaOrgans/Tissues associated with A4GALT sirna
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with A4GALT and Carcinoma
 Lymphoma Antibodies  >1 publications with A4GALT and Lymphoma
 Inflammation Antibodies  >1 publications with A4GALT and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >1 publications with A4GALT and Ovary
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