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A4GNT sirna

Scan QR to view Datasheet Catalog #    MBS828787 A4GNT sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A4GNT, siRNA

★Popular Item★
 Also Known As   

A4GNT siRNA (Human)

 Product Synonym Names    Alpha-1.4-N-acetylglucosaminyltransferase; Alpha4GnT
 Product Gene Name   

A4GNT sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9UNA3
 Host    Synthetic
 Species Reactivity    Human
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 Specificity    A4GNT siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human A4GNT gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of A4GNT sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for A4GNT sirna

   siRNA to inhibit A4GNT expression using RNA interference
 Applications Tested/Suitable for A4GNT sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for A4GNT. It may not necessarily be applicable to this product.
 NCBI GI #    7705859
 NCBI GeneID    51146
 NCBI Accession #    NP_057245.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016161.2 [Other Products]
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 UniProt Primary Accession #    Q9UNA3 [Other Products]
 UniProt Secondary Accession #    Q0VDK1; Q0VDK2 [Other Products]
 UniProt Related Accession #    Q9UNA3 [Other Products]
 Molecular Weight    39,497 Da
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 NCBI Official Full Name    alpha-1,4-N-acetylglucosaminyltransferase
 NCBI Official Synonym Full Names    alpha-1,4-N-acetylglucosaminyltransferase
 NCBI Official Symbol    A4GNT [Similar Products]
 NCBI Official Synonym Symbols   
alpha4GnT
[Similar Products]
 NCBI Protein Information    alpha-1,4-N-acetylglucosaminyltransferase
 UniProt Protein Name    Alpha-1,4-N-acetylglucosaminyltransferase
 Protein Family    Alpha-1,4-N-acetylglucosaminyltransferase
 UniProt Gene Name    A4GNT [Similar Products]
 UniProt Synonym Gene Names    Alpha4GnT [Similar Products]
 UniProt Entry Name    A4GCT_HUMAN
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 NCBI Summary for A4GNT    This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]
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 UniProt Comments for A4GNT    A4GNT: Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O- glycans. Belongs to the glycosyltransferase 32 family.

Protein type: EC 2.4.1.-; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: acetylglucosaminyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; glycoprotein biosynthetic process; carbohydrate metabolic process; negative regulation of epithelial cell proliferation
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 Research Articles on A4GNT    1. human alpha1,4-N-acetylglucosaminyltransferase (alpha4GnT) is responsible for O-glycan biosynthesis and has a role in preventing gastric cancer by inhibiting H. pylori infection and also suppressing tumor-promoting inflammation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with A4GNT sirnaPathways associated with A4GNT sirna
 Reference Product  PubMed Publications
 MUC6 sirna  >2 publications with A4GNT and MUC6
 Products by Pathway  Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram
Organs/Tissues associated with A4GNT sirna
 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >3 publications with A4GNT and Stomach
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